TY  - JOUR
AU  - Hansen, Niels
AU  - Wiltfang, Jens
TI  - Fluid biomarkers unveil signatures of pathological aging.
JO  - Seizure
VL  - 128
SN  - 1059-1311
CY  - Oxford [u.a.]
PB  - Elsevier
M1  - DZNE-2025-00650
SP  - 24 - 28
PY  - 2025
AB  - Aging is a multifaceted and highly varied process in the brain. Identifying aging biomarkers is one means of distinguishing pathological from physiological aging. The aim of this narrative review is to focus on two new developments in the field of fluid biomarkers and draw attention to this excellent tool for the early detection of potential brain pathologies that delay, alter, or enable physiological aging to become pathological. Pathological aging can lower the threshold for the development of specific diseases such as late-onset epilepsy. Fluid biomarkers can reveal pathological levels at an early stage and thus indicate disease processes in the brain that begin before symptoms develop; they thus differ from physiological aging.
KW  - Humans
KW  - Biomarkers: cerebrospinal fluid
KW  - Aging: pathology
KW  - Aging: cerebrospinal fluid
KW  - Epilepsy: cerebrospinal fluid
KW  - Brain: pathology
KW  - Blood biomarkers (Other)
KW  - Fluid biomarkers (Other)
KW  - Inflammaging (Other)
KW  - Late-onset epilepsy (Other)
KW  - Neural autoantibodies (Other)
KW  - Pathological and physiological aging (Other)
KW  - Biomarkers (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:38871529
DO  - DOI:10.1016/j.seizure.2024.05.019
UR  - https://pub.dzne.de/record/278924
ER  -