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@ARTICLE{Hansen:278924,
      author       = {Hansen, Niels and Wiltfang, Jens},
      title        = {{F}luid biomarkers unveil signatures of pathological
                      aging.},
      journal      = {Seizure},
      volume       = {128},
      issn         = {1059-1311},
      address      = {Oxford [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2025-00650},
      pages        = {24 - 28},
      year         = {2025},
      abstract     = {Aging is a multifaceted and highly varied process in the
                      brain. Identifying aging biomarkers is one means of
                      distinguishing pathological from physiological aging. The
                      aim of this narrative review is to focus on two new
                      developments in the field of fluid biomarkers and draw
                      attention to this excellent tool for the early detection of
                      potential brain pathologies that delay, alter, or enable
                      physiological aging to become pathological. Pathological
                      aging can lower the threshold for the development of
                      specific diseases such as late-onset epilepsy. Fluid
                      biomarkers can reveal pathological levels at an early stage
                      and thus indicate disease processes in the brain that begin
                      before symptoms develop; they thus differ from physiological
                      aging.},
      subtyp        = {Review Article},
      keywords     = {Humans / Biomarkers: cerebrospinal fluid / Aging: pathology
                      / Aging: cerebrospinal fluid / Epilepsy: cerebrospinal fluid
                      / Brain: pathology / Blood biomarkers (Other) / Fluid
                      biomarkers (Other) / Inflammaging (Other) / Late-onset
                      epilepsy (Other) / Neural autoantibodies (Other) /
                      Pathological and physiological aging (Other) / Biomarkers
                      (NLM Chemicals)},
      cin          = {AG Wiltfang},
      ddc          = {610},
      cid          = {I:(DE-2719)1410006},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38871529},
      doi          = {10.1016/j.seizure.2024.05.019},
      url          = {https://pub.dzne.de/record/278924},
}