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000278997 1001_ $$aKashani, Amir H$$b0
000278997 245__ $$aRetinal optical coherence tomography angiography imaging in population studies for study of microvascular dysfunction in Alzheimer's disease and related dementias.
000278997 260__ $$aHoboken, NJ$$bWiley$$c2025
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000278997 520__ $$aWidespread use of retinal optical coherence tomography angiography (OCT-A) imaging requires methodological and analytical consensus to ensure reproducible and accurate results in epidemiological studies on Alzheimer's disease and related dementias (ADRD).A consensus framework for assessment of fovea-centered 3 × 3-mm and 6 × 6-mm OCT-A image quality was developed, and reproducibility was reported. Agreement was assessed for overall image quality and image quality relevant for vessel density (VD) quantification and foveal avascular zone (FAZ) metrics. An analytic framework was also developed.Intergrader agreements for overall 3 × 3 mm image quality and quantitative assessment of VD and FAZ ranged between 71% and 87% (52 images). Intragrader agreements ranged between 82% and 93% (n = 27 images). Intergrader agreements were similar for 6 × 6-mm images. Three analytic scenarios were developed to account for bias that may result from image quality and ocular comorbidities.These recommendations provide a framework for working with OCT-A imaging in epidemiological studies on ADRD.Multicentric consensus on quality criteria for use of optical coherence tomography angiography (OCT-A) images in population studies was achieved, considering commonly used protocols acquired with commercially available devices (Heidelberg, Zeiss, and Topcon). Considerable inter- and intrarater agreement was achieved for assessment of OCT-A image quality. A framework for harmonized data analyses was designed. Standardized analyses may accelerate the development of scalable retinal imaging biomarkers for ADRD.
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000278997 650_7 $$2Other$$aAlzheimer's disease and related dementias
000278997 650_7 $$2Other$$aaccelerated cognitive ageing
000278997 650_7 $$2Other$$aepidemiology
000278997 650_7 $$2Other$$aharmonization
000278997 650_7 $$2Other$$aimaging
000278997 650_7 $$2Other$$amicrovascular dysfunction
000278997 650_7 $$2Other$$aneurodegenerative disease
000278997 650_7 $$2Other$$aoptical coherence tomography angiography
000278997 650_7 $$2Other$$apopulation‐based study
000278997 650_7 $$2Other$$aretinal imaging
000278997 650_2 $$2MeSH$$aHumans
000278997 650_2 $$2MeSH$$aTomography, Optical Coherence: methods
000278997 650_2 $$2MeSH$$aAlzheimer Disease: diagnostic imaging
000278997 650_2 $$2MeSH$$aRetinal Vessels: diagnostic imaging
000278997 650_2 $$2MeSH$$aReproducibility of Results
000278997 650_2 $$2MeSH$$aFluorescein Angiography: methods
000278997 650_2 $$2MeSH$$aFemale
000278997 650_2 $$2MeSH$$aDementia: diagnostic imaging
000278997 650_2 $$2MeSH$$aMale
000278997 650_2 $$2MeSH$$aAged
000278997 693__ $$0EXP:(DE-2719)Rhineland Study-20190321$$5EXP:(DE-2719)Rhineland Study-20190321$$eRhineland Study / Bonn$$x0
000278997 7001_ $$aBerendschot, Tos T J M$$b1
000278997 7001_ $$aBonnin, Sophie$$b2
000278997 7001_ $$aSobrin, Lucia$$b3
000278997 7001_ $$aDe Jesus, Danilo Andrade$$b4
000278997 7001_ $$aBrea, Luisa Sanchez$$b5
000278997 7001_ $$aMartinez, Ana Collazo$$b6
000278997 7001_ $$aRaman, Rajiv$$b7
000278997 7001_ $$ade Vries, Victor A$$b8
000278997 7001_ $$0P:(DE-2719)9002740$$aHuang, Haifan$$b9$$udzne
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000278997 7001_ $$aStudy, for the Maastricht$$b11$$eCollaboration Author
000278997 7001_ $$aStudy, Framingham Heart$$b12$$eCollaboration Author
000278997 7001_ $$aStudy, Rotterdam$$b13$$eCollaboration Author
000278997 7001_ $$aStudy, Rhineland$$b14$$eCollaboration Author
000278997 7001_ $$aStudy, SIGNATR$$b15$$eCollaboration Author
000278997 7001_ $$aMacGillivray, Tom$$b16
000278997 7001_ $$aRamdas, Wishal D$$b17
000278997 7001_ $$avan der Heide, Frank C T$$b18
000278997 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.70252$$gVol. 21, no. 6, p. e70252$$n6$$pe70252$$tAlzheimer's and dementia$$v21$$x1552-5260$$y2025
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