Journal Article

DZNE-2025-00661

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Retinal optical coherence tomography angiography imaging in population studies for study of microvascular dysfunction in Alzheimer's disease and related dementias.

Kashani, A. H. ; Berendschot, T. T. J. M. ; Bonnin, S. ; Sobrin, L. ; De Jesus, D. A. ; Brea, L. S. ; Martinez, A. C. ; Raman, R. ; de Vries, V. A. ; Huang, H.DZNE* ; consortium, E. ; Study, f. t. M. (Collaboration Author) ; Study, F. H. (Collaboration Author) ; Study, R. (Collaboration Author) ; Study, R. (Collaboration Author) ; Study, S. (Collaboration Author) ; MacGillivray, T. ; Ramdas, W. D. ; van der Heide, F. C. T.

2025
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/alz.70252

Abstract: Widespread use of retinal optical coherence tomography angiography (OCT-A) imaging requires methodological and analytical consensus to ensure reproducible and accurate results in epidemiological studies on Alzheimer's disease and related dementias (ADRD).A consensus framework for assessment of fovea-centered 3 × 3-mm and 6 × 6-mm OCT-A image quality was developed, and reproducibility was reported. Agreement was assessed for overall image quality and image quality relevant for vessel density (VD) quantification and foveal avascular zone (FAZ) metrics. An analytic framework was also developed.Intergrader agreements for overall 3 × 3 mm image quality and quantitative assessment of VD and FAZ ranged between 71% and 87% (52 images). Intragrader agreements ranged between 82% and 93% (n = 27 images). Intergrader agreements were similar for 6 × 6-mm images. Three analytic scenarios were developed to account for bias that may result from image quality and ocular comorbidities.These recommendations provide a framework for working with OCT-A imaging in epidemiological studies on ADRD.Multicentric consensus on quality criteria for use of optical coherence tomography angiography (OCT-A) images in population studies was achieved, considering commonly used protocols acquired with commercially available devices (Heidelberg, Zeiss, and Topcon). Considerable inter- and intrarater agreement was achieved for assessment of OCT-A image quality. A framework for harmonized data analyses was designed. Standardized analyses may accelerate the development of scalable retinal imaging biomarkers for ADRD.

Keyword(s): Humans (MeSH) ; Tomography, Optical Coherence: methods (MeSH) ; Alzheimer Disease: diagnostic imaging (MeSH) ; Retinal Vessels: diagnostic imaging (MeSH) ; Reproducibility of Results (MeSH) ; Fluorescein Angiography: methods (MeSH) ; Female (MeSH) ; Dementia: diagnostic imaging (MeSH) ; Male (MeSH) ; Aged (MeSH) ; Alzheimer's disease and related dementias ; accelerated cognitive ageing ; epidemiology ; harmonization ; imaging ; microvascular dysfunction ; neurodegenerative disease ; optical coherence tomography angiography ; population‐based study ; retinal imaging

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Contributing Institute(s):

1. Population Health Sciences (AG Breteler)

Research Program(s):

1. 354 - Disease Prevention and Healthy Aging (POF4-354) (POF4-354)

Experiment(s):

1. Rhineland Study / Bonn

Appears in the scientific report 2025

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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