TY  - JOUR
AU  - Kashani, Amir H
AU  - Berendschot, Tos T J M
AU  - Bonnin, Sophie
AU  - Sobrin, Lucia
AU  - De Jesus, Danilo Andrade
AU  - Brea, Luisa Sanchez
AU  - Martinez, Ana Collazo
AU  - Raman, Rajiv
AU  - de Vries, Victor A
AU  - Huang, Haifan
AU  - consortium, E3
AU  - MacGillivray, Tom
AU  - Ramdas, Wishal D
AU  - van der Heide, Frank C T
TI  - Retinal optical coherence tomography angiography imaging in population studies for study of microvascular dysfunction in Alzheimer's disease and related dementias.
JO  - Alzheimer's and dementia
VL  - 21
IS  - 6
SN  - 1552-5260
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2025-00661
SP  - e70252
PY  - 2025
AB  - Widespread use of retinal optical coherence tomography angiography (OCT-A) imaging requires methodological and analytical consensus to ensure reproducible and accurate results in epidemiological studies on Alzheimer's disease and related dementias (ADRD).A consensus framework for assessment of fovea-centered 3 × 3-mm and 6 × 6-mm OCT-A image quality was developed, and reproducibility was reported. Agreement was assessed for overall image quality and image quality relevant for vessel density (VD) quantification and foveal avascular zone (FAZ) metrics. An analytic framework was also developed.Intergrader agreements for overall 3 × 3 mm image quality and quantitative assessment of VD and FAZ ranged between 71
KW  - Humans
KW  - Tomography, Optical Coherence: methods
KW  - Alzheimer Disease: diagnostic imaging
KW  - Retinal Vessels: diagnostic imaging
KW  - Reproducibility of Results
KW  - Fluorescein Angiography: methods
KW  - Female
KW  - Dementia: diagnostic imaging
KW  - Male
KW  - Aged
KW  - Alzheimer's disease and related dementias (Other)
KW  - accelerated cognitive ageing (Other)
KW  - epidemiology (Other)
KW  - harmonization (Other)
KW  - imaging (Other)
KW  - microvascular dysfunction (Other)
KW  - neurodegenerative disease (Other)
KW  - optical coherence tomography angiography (Other)
KW  - population‐based study (Other)
KW  - retinal imaging (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40457754
DO  - DOI:10.1002/alz.70252
UR  - https://pub.dzne.de/record/278997
ER  -