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@ARTICLE{Kashani:278997,
      author       = {Kashani, Amir H and Berendschot, Tos T J M and Bonnin,
                      Sophie and Sobrin, Lucia and De Jesus, Danilo Andrade and
                      Brea, Luisa Sanchez and Martinez, Ana Collazo and Raman,
                      Rajiv and de Vries, Victor A and Huang, Haifan and
                      consortium, E3 and MacGillivray, Tom and Ramdas, Wishal D
                      and van der Heide, Frank C T},
      collaboration = {Study, for the Maastricht and Study, Framingham Heart and
                      Study, Rotterdam and Study, Rhineland and Study, SIGNATR},
      title        = {{R}etinal optical coherence tomography angiography imaging
                      in population studies for study of microvascular dysfunction
                      in {A}lzheimer's disease and related dementias.},
      journal      = {Alzheimer's and dementia},
      volume       = {21},
      number       = {6},
      issn         = {1552-5260},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2025-00661},
      pages        = {e70252},
      year         = {2025},
      abstract     = {Widespread use of retinal optical coherence tomography
                      angiography (OCT-A) imaging requires methodological and
                      analytical consensus to ensure reproducible and accurate
                      results in epidemiological studies on Alzheimer's disease
                      and related dementias (ADRD).A consensus framework for
                      assessment of fovea-centered 3 × 3-mm and 6 × 6-mm OCT-A
                      image quality was developed, and reproducibility was
                      reported. Agreement was assessed for overall image quality
                      and image quality relevant for vessel density (VD)
                      quantification and foveal avascular zone (FAZ) metrics. An
                      analytic framework was also developed.Intergrader agreements
                      for overall 3 × 3 mm image quality and quantitative
                      assessment of VD and FAZ ranged between $71\%$ and $87\%$
                      (52 images). Intragrader agreements ranged between $82\%$
                      and $93\%$ (n = 27 images). Intergrader agreements were
                      similar for 6 × 6-mm images. Three analytic scenarios were
                      developed to account for bias that may result from image
                      quality and ocular comorbidities.These recommendations
                      provide a framework for working with OCT-A imaging in
                      epidemiological studies on ADRD.Multicentric consensus on
                      quality criteria for use of optical coherence tomography
                      angiography (OCT-A) images in population studies was
                      achieved, considering commonly used protocols acquired with
                      commercially available devices (Heidelberg, Zeiss, and
                      Topcon). Considerable inter- and intrarater agreement was
                      achieved for assessment of OCT-A image quality. A framework
                      for harmonized data analyses was designed. Standardized
                      analyses may accelerate the development of scalable retinal
                      imaging biomarkers for ADRD.},
      keywords     = {Humans / Tomography, Optical Coherence: methods / Alzheimer
                      Disease: diagnostic imaging / Retinal Vessels: diagnostic
                      imaging / Reproducibility of Results / Fluorescein
                      Angiography: methods / Female / Dementia: diagnostic imaging
                      / Male / Aged / Alzheimer's disease and related dementias
                      (Other) / accelerated cognitive ageing (Other) /
                      epidemiology (Other) / harmonization (Other) / imaging
                      (Other) / microvascular dysfunction (Other) /
                      neurodegenerative disease (Other) / optical coherence
                      tomography angiography (Other) / population‐based study
                      (Other) / retinal imaging (Other)},
      cin          = {AG Breteler},
      ddc          = {610},
      cid          = {I:(DE-2719)1012001},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-354},
      experiment   = {EXP:(DE-2719)Rhineland Study-20190321},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40457754},
      doi          = {10.1002/alz.70252},
      url          = {https://pub.dzne.de/record/278997},
}