| 001 | 278997 | ||
| 005 | 20250713001342.0 | ||
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| 024 | 7 | _ | |a 1552-5260 |2 ISSN |
| 024 | 7 | _ | |a 1552-5279 |2 ISSN |
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| 037 | _ | _ | |a DZNE-2025-00661 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Kashani, Amir H |b 0 |
| 245 | _ | _ | |a Retinal optical coherence tomography angiography imaging in population studies for study of microvascular dysfunction in Alzheimer's disease and related dementias. |
| 260 | _ | _ | |a Hoboken, NJ |c 2025 |b Wiley |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1748955076_19908 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Widespread use of retinal optical coherence tomography angiography (OCT-A) imaging requires methodological and analytical consensus to ensure reproducible and accurate results in epidemiological studies on Alzheimer's disease and related dementias (ADRD).A consensus framework for assessment of fovea-centered 3 × 3-mm and 6 × 6-mm OCT-A image quality was developed, and reproducibility was reported. Agreement was assessed for overall image quality and image quality relevant for vessel density (VD) quantification and foveal avascular zone (FAZ) metrics. An analytic framework was also developed.Intergrader agreements for overall 3 × 3 mm image quality and quantitative assessment of VD and FAZ ranged between 71% and 87% (52 images). Intragrader agreements ranged between 82% and 93% (n = 27 images). Intergrader agreements were similar for 6 × 6-mm images. Three analytic scenarios were developed to account for bias that may result from image quality and ocular comorbidities.These recommendations provide a framework for working with OCT-A imaging in epidemiological studies on ADRD.Multicentric consensus on quality criteria for use of optical coherence tomography angiography (OCT-A) images in population studies was achieved, considering commonly used protocols acquired with commercially available devices (Heidelberg, Zeiss, and Topcon). Considerable inter- and intrarater agreement was achieved for assessment of OCT-A image quality. A framework for harmonized data analyses was designed. Standardized analyses may accelerate the development of scalable retinal imaging biomarkers for ADRD. |
| 536 | _ | _ | |a 354 - Disease Prevention and Healthy Aging (POF4-354) |0 G:(DE-HGF)POF4-354 |c POF4-354 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a Alzheimer's disease and related dementias |2 Other |
| 650 | _ | 7 | |a accelerated cognitive ageing |2 Other |
| 650 | _ | 7 | |a epidemiology |2 Other |
| 650 | _ | 7 | |a harmonization |2 Other |
| 650 | _ | 7 | |a imaging |2 Other |
| 650 | _ | 7 | |a microvascular dysfunction |2 Other |
| 650 | _ | 7 | |a neurodegenerative disease |2 Other |
| 650 | _ | 7 | |a optical coherence tomography angiography |2 Other |
| 650 | _ | 7 | |a population‐based study |2 Other |
| 650 | _ | 7 | |a retinal imaging |2 Other |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Tomography, Optical Coherence: methods |2 MeSH |
| 650 | _ | 2 | |a Alzheimer Disease: diagnostic imaging |2 MeSH |
| 650 | _ | 2 | |a Retinal Vessels: diagnostic imaging |2 MeSH |
| 650 | _ | 2 | |a Reproducibility of Results |2 MeSH |
| 650 | _ | 2 | |a Fluorescein Angiography: methods |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Dementia: diagnostic imaging |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Aged |2 MeSH |
| 693 | _ | _ | |0 EXP:(DE-2719)Rhineland Study-20190321 |5 EXP:(DE-2719)Rhineland Study-20190321 |e Rhineland Study / Bonn |x 0 |
| 700 | 1 | _ | |a Berendschot, Tos T J M |b 1 |
| 700 | 1 | _ | |a Bonnin, Sophie |b 2 |
| 700 | 1 | _ | |a Sobrin, Lucia |b 3 |
| 700 | 1 | _ | |a De Jesus, Danilo Andrade |b 4 |
| 700 | 1 | _ | |a Brea, Luisa Sanchez |b 5 |
| 700 | 1 | _ | |a Martinez, Ana Collazo |b 6 |
| 700 | 1 | _ | |a Raman, Rajiv |b 7 |
| 700 | 1 | _ | |a de Vries, Victor A |b 8 |
| 700 | 1 | _ | |a Huang, Haifan |0 P:(DE-2719)9002740 |b 9 |u dzne |
| 700 | 1 | _ | |a consortium, E3 |b 10 |
| 700 | 1 | _ | |a Study, for the Maastricht |b 11 |e Collaboration Author |
| 700 | 1 | _ | |a Study, Framingham Heart |b 12 |e Collaboration Author |
| 700 | 1 | _ | |a Study, Rotterdam |b 13 |e Collaboration Author |
| 700 | 1 | _ | |a Study, Rhineland |b 14 |e Collaboration Author |
| 700 | 1 | _ | |a Study, SIGNATR |b 15 |e Collaboration Author |
| 700 | 1 | _ | |a MacGillivray, Tom |b 16 |
| 700 | 1 | _ | |a Ramdas, Wishal D |b 17 |
| 700 | 1 | _ | |a van der Heide, Frank C T |b 18 |
| 773 | _ | _ | |a 10.1002/alz.70252 |g Vol. 21, no. 6, p. e70252 |0 PERI:(DE-600)2201940-6 |n 6 |p e70252 |t Alzheimer's and dementia |v 21 |y 2025 |x 1552-5260 |
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