TY  - JOUR
AU  - Boura, Iro
AU  - Poplawska-Domaszewicz, Karolina
AU  - Spanaki, Cleanthe
AU  - Chen, Rosabel
AU  - Urso, Daniele
AU  - van Coller, Riaan
AU  - Storch, Alexander
AU  - Chaudhuri, Kallol Ray
TI  - Non-Motor Fluctuations in Parkinson’s Disease: Underdiagnosed Yet Important
JO  - Journal of movement disorders
VL  - 18
IS  - 1
SN  - 2005-940X
CY  - Seoul
PB  - Korean Movement Disorder Society
M1  - DZNE-2025-00703
SP  - 1 - 16
PY  - 2025
AB  - Non-motor fluctuations (NMFs) in Parkinson's disease (PD) significantly affect patients' well-being. Despite being identified over two decades ago, NMFs remain largely underrecognized, undertreated, and poorly understood. While they are often temporally associated with motor fluctuations (MFs) and can share common risk factors and pathophysiologic mechanisms, NMFs and MFs are currently considered distinct entities. The prevalence and severity of NMFs, often categorized into neuropsychiatric, sensory, and autonomic subtypes, vary significantly across studies due to the heterogeneous PD populations screened and the diverse evaluation tools applied. The consistent negative impact of NMFs on PD patients' quality of life underscores the importance of further investigations via focused and controlled studies, validated assessment instruments and novel digital technologies. High-quality research is essential to illuminate the complex pathophysiology and clinical nuances of NMFs, ultimately enhancing clinicians' diagnostic and treatment options in routine clinical practice.
KW  - Advanced (Other)
KW  - Fluctuations (Other)
KW  - Non-motor (Other)
KW  - Parkinson’s disease (Other)
KW  - Therapy (Other)
LB  - PUB:(DE-HGF)16
DO  - DOI:10.14802/jmd.24227
UR  - https://pub.dzne.de/record/279175
ER  -