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001     279457
005     20250716101213.0
024 7 _ |a 10.1038/s41598-025-06911-z
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037 _ _ |a DZNE-2025-00784
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082 _ _ |a 600
100 1 _ |a Landstra, Elvire-Nadieh
|0 P:(DE-2719)9000634
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245 _ _ |a Sex-specific relations of ceramides and white matter hyperintensities in the Rhineland study.
260 _ _ |a [London]
|c 2025
|b Springer Nature
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520 _ _ |a Women have a higher white matter hyperintensity (WMH) burden compared to men of a similar age, but the causes of this remain unclear. Ceramide (CER) levels differ between men and women and were previously linked to WMH, suggesting they could underlie these sex differences. Therefore, we associated twelve CERs, CER totals, six CER ratios, and a CER score reflecting the CERs most strongly associated with cardiovascular disease, with WMH load in 3,283 participants (30-95 years) of the community-based Rhineland Study. We assessed sex-specific relations between CERs and WMH by including an interaction term and performing sex-stratified analyses. We further investigated the influence of menopause by comparing relations in pre- and postmenopausal women of the same age. Multiple CERs, CER ratios, and the CER score were associated with increased WMH load, with most associations being significantly stronger in women than in men. We found no influence of menopausal status on the associations between CERs and WMH. Thus, we showed novel and strong associations of CERs, CER ratios and the CER score with WMH burden, especially in women. This study suggests that CERs may play an important role in the observed sex differences in WMH burden.
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650 _ 7 |a Brain lipids
|2 Other
650 _ 7 |a Ceramides
|2 Other
650 _ 7 |a Epidemiology
|2 Other
650 _ 7 |a Menopause
|2 Other
650 _ 7 |a Sex differences
|2 Other
650 _ 7 |a White matter hyperintensities
|2 Other
650 _ 7 |a Ceramides
|2 NLM Chemicals
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Ceramides: metabolism
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a White Matter: metabolism
|2 MeSH
650 _ 2 |a White Matter: diagnostic imaging
|2 MeSH
650 _ 2 |a White Matter: pathology
|2 MeSH
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Aged, 80 and over
|2 MeSH
650 _ 2 |a Sex Factors
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a Sex Characteristics
|2 MeSH
650 _ 2 |a Menopause
|2 MeSH
693 _ _ |0 EXP:(DE-2719)Rhineland Study-20190321
|5 EXP:(DE-2719)Rhineland Study-20190321
|e Rhineland Study / Bonn
|x 0
700 1 _ |a Lohner, Valerie
|0 P:(DE-2719)2811856
|b 1
|e First author
700 1 _ |a Breteler, Monique M B
|0 P:(DE-2719)2810403
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773 _ _ |a 10.1038/s41598-025-06911-z
|g Vol. 15, no. 1, p. 23757
|0 PERI:(DE-600)2615211-3
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|p 23757
|t Scientific reports
|v 15
|y 2025
|x 2045-2322
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