Journal Article

DZNE-2025-00784

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Sex-specific relations of ceramides and white matter hyperintensities in the Rhineland study.

Landstra, E.-N. (First author)DZNE* ; Lohner, V. (First author)DZNE* ; Breteler, M. M. B. (Last author)DZNE*

2025
Springer Nature [London]

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Please use a persistent id in citations: doi:10.1038/s41598-025-06911-z

Abstract: Women have a higher white matter hyperintensity (WMH) burden compared to men of a similar age, but the causes of this remain unclear. Ceramide (CER) levels differ between men and women and were previously linked to WMH, suggesting they could underlie these sex differences. Therefore, we associated twelve CERs, CER totals, six CER ratios, and a CER score reflecting the CERs most strongly associated with cardiovascular disease, with WMH load in 3,283 participants (30-95 years) of the community-based Rhineland Study. We assessed sex-specific relations between CERs and WMH by including an interaction term and performing sex-stratified analyses. We further investigated the influence of menopause by comparing relations in pre- and postmenopausal women of the same age. Multiple CERs, CER ratios, and the CER score were associated with increased WMH load, with most associations being significantly stronger in women than in men. We found no influence of menopausal status on the associations between CERs and WMH. Thus, we showed novel and strong associations of CERs, CER ratios and the CER score with WMH burden, especially in women. This study suggests that CERs may play an important role in the observed sex differences in WMH burden.

Keyword(s): Humans (MeSH) ; Ceramides: metabolism (MeSH) ; Female (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Aged (MeSH) ; White Matter: metabolism (MeSH) ; White Matter: diagnostic imaging (MeSH) ; White Matter: pathology (MeSH) ; Adult (MeSH) ; Aged, 80 and over (MeSH) ; Sex Factors (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Sex Characteristics (MeSH) ; Menopause (MeSH) ; Brain lipids ; Ceramides ; Epidemiology ; Menopause ; Sex differences ; White matter hyperintensities ; Ceramides

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Contributing Institute(s):

1. Population Health Sciences (AG Breteler)

Research Program(s):

1. 354 - Disease Prevention and Healthy Aging (POF4-354) (POF4-354)

Experiment(s):

1. Rhineland Study / Bonn

Appears in the scientific report 2025

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