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000279476 037__ $$aDZNE-2025-00803
000279476 1001_ $$0P:(DE-2719)2811660$$aSchultze, Joachim$$b0$$udzne
000279476 245__ $$aDataset: Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment
000279476 260__ $$bHuman Cell Atlas Data Explorer$$c2025
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000279476 520__ $$aCoronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19 associated with increased neutrophil counts and dysregulated immune responses remain unclear. In a dual-center, two-cohort study, we combined single-cell RNA-sequencing and single-cell proteomics of whole-blood and peripheral-blood mononuclear cells to determine changes in immune cell composition and activation in mild versus severe COVID-19 (242 samples from 109 individuals) over time. HLA-DRhiCD11chi inflammatory monocytes with an interferon-stimulated gene signature were elevated in mild COVID-19. Severe COVID-19 was marked by occurrence of neutrophil precursors, as evidence of emergency myelopoiesis, dysfunctional mature neutrophils, and HLA-DRlo monocytes. Our study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.
000279476 536__ $$0G:(DE-HGF)POF4-354$$a354 - Disease Prevention and Healthy Aging (POF4-354)$$cPOF4-354$$fPOF IV$$x0
000279476 7001_ $$0P:(DE-2719)9000846$$ade Domenico, Elena$$b1$$udzne
000279476 7001_ $$0P:(DE-2719)2812564$$aSaglam, Adem$$b2$$udzne
000279476 7001_ $$0P:(DE-2719)2812302$$aDrews, Anna-Dorothee$$b3$$udzne
000279476 7001_ $$0P:(DE-2719)9000845$$aUlas, Thomas$$b4$$udzne
000279476 7001_ $$0P:(DE-2719)2812750$$aBecker, Matthias Kai Holger$$b5$$udzne
000279476 7001_ $$0P:(DE-2719)2812735$$aHändler, Kristian$$b6$$udzne
000279476 7870_ $$0DZNE-2021-00219$$aSchulte-Schrepping, Jonas et.al.$$dNew York, NY : Elsevier, 2020$$iRelatedTo$$r$$tSevere COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.
000279476 8564_ $$uhttps://explore.data.humancellatlas.org/projects/cd9d6360-ce38-4321-97df-f13c79e3cb84
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000279476 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811660$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000279476 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000846$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000279476 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812564$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
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000279476 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812750$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000279476 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812735$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b6$$kDZNE
000279476 9131_ $$0G:(DE-HGF)POF4-354$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Prevention and Healthy Aging$$x0
000279476 9141_ $$y2025
000279476 9201_ $$0I:(DE-2719)1013038$$kAG Schultze$$lClinical Single Cell Omics (CSCO) / Systems Medicine$$x0
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