guest ::
| Home > Publications Database > Dataset: Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment |
| Home > Publications Database > Dataset: Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment |
| Dataset | DZNE-2025-00803 |
; ; ; ; ; ;
2025
Human Cell Atlas Data Explorer
Abstract: Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19 associated with increased neutrophil counts and dysregulated immune responses remain unclear. In a dual-center, two-cohort study, we combined single-cell RNA-sequencing and single-cell proteomics of whole-blood and peripheral-blood mononuclear cells to determine changes in immune cell composition and activation in mild versus severe COVID-19 (242 samples from 109 individuals) over time. HLA-DRhiCD11chi inflammatory monocytes with an interferon-stimulated gene signature were elevated in mild COVID-19. Severe COVID-19 was marked by occurrence of neutrophil precursors, as evidence of emergency myelopoiesis, dysfunctional mature neutrophils, and HLA-DRlo monocytes. Our study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.
|
The record appears in these collections: |
Journal Article
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.
Cell 182(6), 1419 - 1440.e23 (2020) [10.1016/j.cell.2020.08.001]
Files Fulltext by Pubmed Central
BibTeX |
EndNote:
XML,
Text |
RIS
