TY  - CHART
AU  - Schultze, Joachim
AU  - de Domenico, Elena
AU  - Saglam, Adem
AU  - Drews, Anna-Dorothee
AU  - Ulas, Thomas
AU  - Becker, Matthias Kai Holger
AU  - Händler, Kristian
TI  - Dataset: Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment
PB  - Human Cell Atlas Data Explorer
M1  - DZNE-2025-00803
PY  - 2025
AB  - Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19 associated with increased neutrophil counts and dysregulated immune responses remain unclear. In a dual-center, two-cohort study, we combined single-cell RNA-sequencing and single-cell proteomics of whole-blood and peripheral-blood mononuclear cells to determine changes in immune cell composition and activation in mild versus severe COVID-19 (242 samples from 109 individuals) over time. HLA-DRhiCD11chi inflammatory monocytes with an interferon-stimulated gene signature were elevated in mild COVID-19. Severe COVID-19 was marked by occurrence of neutrophil precursors, as evidence of emergency myelopoiesis, dysfunctional mature neutrophils, and HLA-DRlo monocytes. Our study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.
LB  - PUB:(DE-HGF)32
UR  - https://pub.dzne.de/record/279476
ER  -