% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@MISC{Schultze:279476,
      author       = {Schultze, Joachim and de Domenico, Elena and Saglam, Adem
                      and Drews, Anna-Dorothee and Ulas, Thomas and Becker,
                      Matthias Kai Holger and Händler, Kristian},
      title        = {{D}ataset: {S}evere {COVID}-19 {I}s {M}arked by a
                      {D}ysregulated {M}yeloid {C}ell {C}ompartment},
      publisher    = {Human Cell Atlas Data Explorer},
      reportid     = {DZNE-2025-00803},
      year         = {2025},
      abstract     = {Coronavirus disease 2019 (COVID-19) is a mild to moderate
                      respiratory tract infection, however, a subset of patients
                      progress to severe disease and respiratory failure. The
                      mechanism of protective immunity in mild forms and the
                      pathogenesis of severe COVID-19 associated with increased
                      neutrophil counts and dysregulated immune responses remain
                      unclear. In a dual-center, two-cohort study, we combined
                      single-cell RNA-sequencing and single-cell proteomics of
                      whole-blood and peripheral-blood mononuclear cells to
                      determine changes in immune cell composition and activation
                      in mild versus severe COVID-19 (242 samples from 109
                      individuals) over time. HLA-DRhiCD11chi inflammatory
                      monocytes with an interferon-stimulated gene signature were
                      elevated in mild COVID-19. Severe COVID-19 was marked by
                      occurrence of neutrophil precursors, as evidence of
                      emergency myelopoiesis, dysfunctional mature neutrophils,
                      and HLA-DRlo monocytes. Our study provides detailed insights
                      into the systemic immune response to SARS-CoV-2 infection
                      and reveals profound alterations in the myeloid cell
                      compartment associated with severe COVID-19.},
      cin          = {AG Schultze},
      cid          = {I:(DE-2719)1013038},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-354},
      typ          = {PUB:(DE-HGF)32},
      url          = {https://pub.dzne.de/record/279476},
}