Home > Publications Database > Dataset: Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment > print

001     279476
005     20250709100939.0
037 _ _ |a DZNE-2025-00803
100 1 _ |a Schultze, Joachim
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245 _ _ |a Dataset: Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment
260 _ _ |c 2025
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520 _ _ |a Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19 associated with increased neutrophil counts and dysregulated immune responses remain unclear. In a dual-center, two-cohort study, we combined single-cell RNA-sequencing and single-cell proteomics of whole-blood and peripheral-blood mononuclear cells to determine changes in immune cell composition and activation in mild versus severe COVID-19 (242 samples from 109 individuals) over time. HLA-DRhiCD11chi inflammatory monocytes with an interferon-stimulated gene signature were elevated in mild COVID-19. Severe COVID-19 was marked by occurrence of neutrophil precursors, as evidence of emergency myelopoiesis, dysfunctional mature neutrophils, and HLA-DRlo monocytes. Our study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.
536 _ _ |a 354 - Disease Prevention and Healthy Aging (POF4-354)
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700 1 _ |a de Domenico, Elena
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700 1 _ |a Saglam, Adem
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700 1 _ |a Drews, Anna-Dorothee
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700 1 _ |a Ulas, Thomas
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700 1 _ |a Becker, Matthias Kai Holger
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700 1 _ |a Händler, Kristian
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787 0 _ |a Schulte-Schrepping, Jonas et.al.
|d New York, NY : Elsevier, 2020
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|0 DZNE-2021-00219
|r
|t Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.
856 4 _ |u https://explore.data.humancellatlas.org/projects/cd9d6360-ce38-4321-97df-f13c79e3cb84
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914 1 _ |y 2025
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