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@MISC{Mller:279479,
      author       = {Müller, Stephan A and Lichtenthaler, Stefan},
      title        = {{D}ataset: {Q}uantitative proteomics of {CSF} from the
                      {A}lzheimer's disease mouse model 5x{FAD}},
      publisher    = {PRoteomics IDEntifications Database},
      reportid     = {DZNE-2025-00806},
      year         = {2025},
      abstract     = {The 5xFAD mouse model was used to study the influence of
                      amyloid pathology on the cerebrospinal fluid (CSF) proteome.
                      Therefore, CSF of 7-months old 5xFAD and WT control mice was
                      sampled with an improved collection protocol. Using a minute
                      amount of 5 µL CSF, we applied data dependent and data
                      independent acquisition of the same samples on a Q-Exactive
                      HF mass spectrometer. Comparison of DDA and DIA demonstrate
                      a higher data completeness for DIA. The results show a
                      strong effect on microglia activation exemplified by
                      strongly increased abundances of Trem2 and Cst7.
                      Furthermore, neurodegenerative markers such as
                      neurofilaments and tau (Mapt) were strongly increased for
                      5xFAD mice.},
      cin          = {AG Lichtenthaler},
      cid          = {I:(DE-2719)1110006},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)32},
      url          = {https://pub.dzne.de/record/279479},
}