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| Home > Publications Database > Dataset: Quantitative proteomics of CSF from the Alzheimer's disease mouse model 5xFAD |
| Dataset | DZNE-2025-00806 |
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2025
PRoteomics IDEntifications Database
Abstract: The 5xFAD mouse model was used to study the influence of amyloid pathology on the cerebrospinal fluid (CSF) proteome. Therefore, CSF of 7-months old 5xFAD and WT control mice was sampled with an improved collection protocol. Using a minute amount of 5 µL CSF, we applied data dependent and data independent acquisition of the same samples on a Q-Exactive HF mass spectrometer. Comparison of DDA and DIA demonstrate a higher data completeness for DIA. The results show a strong effect on microglia activation exemplified by strongly increased abundances of Trem2 and Cst7. Furthermore, neurodegenerative markers such as neurofilaments and tau (Mapt) were strongly increased for 5xFAD mice.
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Journal Article
An Improved Method for Sampling and Quantitative Protein Analytics of Cerebrospinal Fluid of Individual Mice.
Molecular & cellular proteomics 24(5), 100958 (2025) [10.1016/j.mcpro.2025.100958]
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