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@MISC{Mller:279491,
      author       = {Müller, Stephan A and Lichtenthaler, Stefan},
      title        = {{D}ataset: {P}lasma proteomics of {BACE}2 {KO} mice},
      publisher    = {PRoteomics IDEntifications Database},
      reportid     = {DZNE-2025-00818},
      year         = {2024},
      abstract     = {The beta-secretase BACE1 is a central drug target for
                      Alzheimer’s disease. Clinically tested, BACE1-directed
                      inhibitors also block the homologous protease BACE2. Yet,
                      little is known about physiological BACE2 substrates and
                      functions in vivo. Here, we performed discovery proteomics
                      to identify substrates of the protease BACE2 in plasma of
                      mice. Therefore, we analysed plasma from BACE2 KO, and WT
                      controls. Inactivation of BACE2 inhibited shedding of
                      VEGFR3/FLT4. Thus, sVEGFR3 represents a pharmacodynamic
                      plasma marker for BACE2 activity in vivo.},
      cin          = {AG Lichtenthaler},
      cid          = {I:(DE-2719)1110006},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)32},
      url          = {https://pub.dzne.de/record/279491},
}