Dataset

DZNE-2025-00818

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dataset: Plasma proteomics of BACE2 KO mice

Müller, S. A.DZNE* ; Lichtenthaler, S.DZNE*

2024
PRoteomics IDEntifications Database

Abstract: The beta-secretase BACE1 is a central drug target for Alzheimer’s disease. Clinically tested, BACE1-directed inhibitors also block the homologous protease BACE2. Yet, little is known about physiological BACE2 substrates and functions in vivo. Here, we performed discovery proteomics to identify substrates of the protease BACE2 in plasma of mice. Therefore, we analysed plasma from BACE2 KO, and WT controls. Inactivation of BACE2 inhibited shedding of VEGFR3/FLT4. Thus, sVEGFR3 represents a pharmacodynamic plasma marker for BACE2 activity in vivo.

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Contributing Institute(s):

1. Neuroproteomics (AG Lichtenthaler)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article Schmidt, A. (First author)DZNE* ; Hrupka, B. ; van Bebber, F.DZNE* ; Sunil Kumar, S. ; Feng, X.DZNE* ; Tschirner, S. K.DZNE* ; Aßfalg, M.DZNE* ; Müller, S. A.DZNE* ; Hilger, L. S.DZNE* ; Hofmann, L. I.DZNE* ; Pigoni, M.DZNE* ; Jocher, G.DZNE* ; Voytyuk, I. ; Self, E. L. ; Ito, M. ; Hyakkoku, K. ; Yoshimura, A. ; Horiguchi, N. ; Feederle, R.DZNE* ; De Strooper, B. ; Schulte-Merker, S. ; Lammert, E. ; Moechars, D. ; Schmid, B.DZNE* ; Lichtenthaler, S. F. (Last author)DZNE*
The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling.
The journal of clinical investigation 134(16), e170550 (2024) [10.1172/JCI170550]2024   Files  Fulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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