| 001 | 279884 | ||
| 005 | 20250716101214.0 | ||
| 024 | 7 | _ | |a 10.1016/j.jphotobiol.2025.113191 |2 doi |
| 024 | 7 | _ | |a pmid:40460513 |2 pmid |
| 024 | 7 | _ | |a 1011-1344 |2 ISSN |
| 024 | 7 | _ | |a 1873-2682 |2 ISSN |
| 037 | _ | _ | |a DZNE-2025-00851 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 540 |
| 100 | 1 | _ | |a Armăşescu, Florian |b 0 |
| 245 | _ | _ | |a Fiber-optic-guided near-infrared laser exposure induces depolarization of cultured primary sensory neurons and modifies biophysical properties of human Nav1.5 channels. |
| 260 | _ | _ | |a New York, NY [u.a.] |c 2025 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1752572404_18055 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Photobiomodulation, a therapeutic method promoting wound healing, reduction in inflammation, pain and apoptosis, was widely tested in neurological/psychiatric disorders. In Parkinson's disease positive results have been obtained recently by transcranial or deep-fiber-optic-based near-infrared (NIR) light application. We assessed the effects of NIR stimulation with a 808.5 nm diode laser applied via a multimode fiber with a sharp tip placed over the cell on enzyme-dissociated cultured adult rat primary sensory neurons and human embryo kidney (HEK293) cells stably expressing human voltage-dependent Na+ channels (Nav1.5) approached via patch-clamp. For each type of cell, specific series of voltage- or current-clamp protocols were applied initially and after 3 min of laser exposure or control conditions. Laser exposure induced in neurons a resting potential depolarization (6.6 ± 1.8 mV vs. 2.4 ± 1.8 mV in control, mean ± SEM, p = 0.0594). In Nav1.5-expressing cells, peak INa amplitude slightly increased after laser application (111.2 ± 14.9 % vs. 70.6 ± 10.4 % in control experiments), and in outside-out patches the differences were larger (96.64 ± 5.25 %-laser vs. 37.95 ± 9.14 %-control). Via chemiluminometry we evidenced a delayed increase in ATP production in laser-exposed HEK293 cells. An explanation of these effects is that NIR exposure facilitates ATP production, maintaining an adequate state of Na+ channels phosphorylation, but we cannot exclude direct polarization effects on macromolecules including ion channels produced by the intense oriented electric field of the laser beam. |
| 536 | _ | _ | |a 351 - Brain Function (POF4-351) |0 G:(DE-HGF)POF4-351 |c POF4-351 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a NIR laser |2 Other |
| 650 | _ | 7 | |a Nav1.5 |2 Other |
| 650 | _ | 7 | |a Patch-clamp |2 Other |
| 650 | _ | 7 | |a Phosphorylation |2 Other |
| 650 | _ | 7 | |a Photobiomodulation |2 Other |
| 650 | _ | 7 | |a Primary sensory neuron |2 Other |
| 650 | _ | 7 | |a NAV1.5 Voltage-Gated Sodium Channel |2 NLM Chemicals |
| 650 | _ | 7 | |a SCN5A protein, human |2 NLM Chemicals |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a HEK293 Cells |2 MeSH |
| 650 | _ | 2 | |a NAV1.5 Voltage-Gated Sodium Channel: metabolism |2 MeSH |
| 650 | _ | 2 | |a Infrared Rays |2 MeSH |
| 650 | _ | 2 | |a Rats |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Sensory Receptor Cells: radiation effects |2 MeSH |
| 650 | _ | 2 | |a Sensory Receptor Cells: metabolism |2 MeSH |
| 650 | _ | 2 | |a Sensory Receptor Cells: cytology |2 MeSH |
| 650 | _ | 2 | |a Lasers |2 MeSH |
| 650 | _ | 2 | |a Cells, Cultured |2 MeSH |
| 650 | _ | 2 | |a Patch-Clamp Techniques |2 MeSH |
| 650 | _ | 2 | |a Membrane Potentials: radiation effects |2 MeSH |
| 700 | 1 | _ | |a Amuzescu, Bogdan |b 1 |
| 700 | 1 | _ | |a Gheorghe, Roxana-Olimpia |b 2 |
| 700 | 1 | _ | |a Ghenghea, Mihail |0 P:(DE-2719)9002399 |b 3 |u dzne |
| 700 | 1 | _ | |a Ristoiu, Violeta |b 4 |
| 700 | 1 | _ | |a Ciurea, Jean |b 5 |
| 700 | 1 | _ | |a Gruia, Ion |b 6 |
| 773 | _ | _ | |a 10.1016/j.jphotobiol.2025.113191 |g Vol. 269, p. 113191 - |0 PERI:(DE-600)1482691-4 |p 113191 |t Journal of photochemistry and photobiology / B |v 269 |y 2025 |x 1011-1344 |
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| 856 | 4 | _ | |u https://pub.dzne.de/record/279884/files/DZNE-2025-00851%20SUP.pdf |
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