%0 Journal Article
%A van de Burgt, Nikita A
%A Kulsvehagen, Laila
%A Mané-Damas, Marina
%A Lutz, Luc
%A Lecourt, Anne-Catherine
%A Monserrat, Clara
%A Vinke, Anita M
%A Küçükali, Cem I
%A Zong, Shenghua
%A Hoffmann, Carolin
%A González-Vioque, Emiliano
%A Arango, Celso
%A Leibold, Nicole K
%A Losen, Mario
%A Molenaar, Peter C
%A Tüzün, Erdem
%A van Beveren, Nico J M
%A Mané, Anna
%A Rouhl, Rob P W
%A van Amelsvoort, Therese A M J
%A Risk, for Genetic
%A Pröbstel, Anne-Katrin
%A Martinez-Martinez, Pilar
%T Autoantibodies against myelin oligodendrocyte glycoprotein in a subgroup of patients with psychotic symptoms.
%J Frontiers in neurology
%V 16
%@ 1664-2295
%C Lausanne
%I Frontiers Research Foundation
%M DZNE-2025-00901
%P 1593042
%D 2025
%X The presence of autoantibodies against myelin oligodendrocyte glycoprotein (MOG) is a hallmark of MOG antibody-associated disease (MOGAD), a recently defined demyelinating disease entity presenting with core clinical features of optic neuritis, myelitis, and acute disseminated encephalomyelitis. Although MOG antibodies have also been described in a small number of patients with other conditions, including mental disorders, their prevalence and clinical specificity in patients with isolated psychotic symptoms remain unclear. Here, we screened sera from 262 patients with at least one psychotic episode and 166 control subjects for the presence of MOG antibodies of the immunoglobulin G (IgG) isotype with a live cell-based assay. Serum reactivity to additional antigens was assessed by immunohistochemistry. Four patients, representing 1.5
%K autoantibodies (Other)
%K mental disorders (Other)
%K myelin oligodendrocyte glycoprotein antibody-associated disease (Other)
%K neuroinflammation (Other)
%K psychiatry (Other)
%K psychosis (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40757033
%2 pmc:PMC12316182
%R 10.3389/fneur.2025.1593042
%U https://pub.dzne.de/record/280223