Journal Article

DZNE-2025-00901

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Autoantibodies against myelin oligodendrocyte glycoprotein in a subgroup of patients with psychotic symptoms.

van de Burgt, N. A. ; Kulsvehagen, L. ; Mané-Damas, M. ; Lutz, L. ; Lecourt, A.-C. ; Monserrat, C. ; Vinke, A. M. ; Küçükali, C. I. ; Zong, S. ; Hoffmann, C. ; González-Vioque, E. ; Arango, C. ; Leibold, N. K. ; Losen, M. ; Molenaar, P. C. ; Tüzün, E. ; van Beveren, N. J. M. ; Mané, A. ; Rouhl, R. P. W. ; van Amelsvoort, T. A. M. J. ; Risk, f. G. ; Psychosis, O. o. (Collaboration Author) ; Pröbstel, A.-K. (Last author)DZNE* ; Martinez-Martinez, P.

2025
Frontiers Research Foundation Lausanne

This record in other databases:    

Please use a persistent id in citations: doi:10.3389/fneur.2025.1593042

Abstract: The presence of autoantibodies against myelin oligodendrocyte glycoprotein (MOG) is a hallmark of MOG antibody-associated disease (MOGAD), a recently defined demyelinating disease entity presenting with core clinical features of optic neuritis, myelitis, and acute disseminated encephalomyelitis. Although MOG antibodies have also been described in a small number of patients with other conditions, including mental disorders, their prevalence and clinical specificity in patients with isolated psychotic symptoms remain unclear. Here, we screened sera from 262 patients with at least one psychotic episode and 166 control subjects for the presence of MOG antibodies of the immunoglobulin G (IgG) isotype with a live cell-based assay. Serum reactivity to additional antigens was assessed by immunohistochemistry. Four patients, representing 1.5% of the patient cohort, and one control individual, representing. 0.6% of the healthy control cohort, were seropositive for MOG-IgG antibodies. Of the four MOG-IgG seropositive patients, three experienced visual hallucinations. Overall, MOG antibodies were detected at a low frequency in patients with psychotic episodes. While we cannot exclude the possibility of false-positive results or seroconversion due to secondary myelin damage, the association with visual hallucinations in three out of four MOG-IgG seropositive patients may point toward an underlying autoimmune etiology.

Keyword(s): autoantibodies ; mental disorders ; myelin oligodendrocyte glycoprotein antibody-associated disease ; neuroinflammation ; psychiatry ; psychosis

---

Contributing Institute(s):

1. Clinical Neurology and Neuroimmunology (AG Pröbstel)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2025

---

Database coverage:
; ; ; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---