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000280223 037__ $$aDZNE-2025-00901
000280223 041__ $$aEnglish
000280223 082__ $$a610
000280223 1001_ $$avan de Burgt, Nikita A$$b0
000280223 245__ $$aAutoantibodies against myelin oligodendrocyte glycoprotein in a subgroup of patients with psychotic symptoms.
000280223 260__ $$aLausanne$$bFrontiers Research Foundation$$c2025
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000280223 520__ $$aThe presence of autoantibodies against myelin oligodendrocyte glycoprotein (MOG) is a hallmark of MOG antibody-associated disease (MOGAD), a recently defined demyelinating disease entity presenting with core clinical features of optic neuritis, myelitis, and acute disseminated encephalomyelitis. Although MOG antibodies have also been described in a small number of patients with other conditions, including mental disorders, their prevalence and clinical specificity in patients with isolated psychotic symptoms remain unclear. Here, we screened sera from 262 patients with at least one psychotic episode and 166 control subjects for the presence of MOG antibodies of the immunoglobulin G (IgG) isotype with a live cell-based assay. Serum reactivity to additional antigens was assessed by immunohistochemistry. Four patients, representing 1.5% of the patient cohort, and one control individual, representing. 0.6% of the healthy control cohort, were seropositive for MOG-IgG antibodies. Of the four MOG-IgG seropositive patients, three experienced visual hallucinations. Overall, MOG antibodies were detected at a low frequency in patients with psychotic episodes. While we cannot exclude the possibility of false-positive results or seroconversion due to secondary myelin damage, the association with visual hallucinations in three out of four MOG-IgG seropositive patients may point toward an underlying autoimmune etiology.
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000280223 650_7 $$2Other$$aautoantibodies
000280223 650_7 $$2Other$$amental disorders
000280223 650_7 $$2Other$$amyelin oligodendrocyte glycoprotein antibody-associated disease
000280223 650_7 $$2Other$$aneuroinflammation
000280223 650_7 $$2Other$$apsychiatry
000280223 650_7 $$2Other$$apsychosis
000280223 7001_ $$aKulsvehagen, Laila$$b1
000280223 7001_ $$aMané-Damas, Marina$$b2
000280223 7001_ $$aLutz, Luc$$b3
000280223 7001_ $$aLecourt, Anne-Catherine$$b4
000280223 7001_ $$aMonserrat, Clara$$b5
000280223 7001_ $$aVinke, Anita M$$b6
000280223 7001_ $$aKüçükali, Cem I$$b7
000280223 7001_ $$aZong, Shenghua$$b8
000280223 7001_ $$aHoffmann, Carolin$$b9
000280223 7001_ $$aGonzález-Vioque, Emiliano$$b10
000280223 7001_ $$aArango, Celso$$b11
000280223 7001_ $$aLeibold, Nicole K$$b12
000280223 7001_ $$aLosen, Mario$$b13
000280223 7001_ $$aMolenaar, Peter C$$b14
000280223 7001_ $$aTüzün, Erdem$$b15
000280223 7001_ $$avan Beveren, Nico J M$$b16
000280223 7001_ $$aMané, Anna$$b17
000280223 7001_ $$aRouhl, Rob P W$$b18
000280223 7001_ $$avan Amelsvoort, Therese A M J$$b19
000280223 7001_ $$aRisk, for Genetic$$b20
000280223 7001_ $$aPsychosis, Outcome of$$b21$$eCollaboration Author
000280223 7001_ $$0P:(DE-2719)9003515$$aPröbstel, Anne-Katrin$$b22$$eLast author$$udzne
000280223 7001_ $$aMartinez-Martinez, Pilar$$b23
000280223 773__ $$0PERI:(DE-600)2564214-5$$a10.3389/fneur.2025.1593042$$gVol. 16, p. 1593042$$p1593042$$tFrontiers in neurology$$v16$$x1664-2295$$y2025
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