TY  - JOUR
AU  - van de Burgt, Nikita A
AU  - Kulsvehagen, Laila
AU  - Mané-Damas, Marina
AU  - Lutz, Luc
AU  - Lecourt, Anne-Catherine
AU  - Monserrat, Clara
AU  - Vinke, Anita M
AU  - Küçükali, Cem I
AU  - Zong, Shenghua
AU  - Hoffmann, Carolin
AU  - González-Vioque, Emiliano
AU  - Arango, Celso
AU  - Leibold, Nicole K
AU  - Losen, Mario
AU  - Molenaar, Peter C
AU  - Tüzün, Erdem
AU  - van Beveren, Nico J M
AU  - Mané, Anna
AU  - Rouhl, Rob P W
AU  - van Amelsvoort, Therese A M J
AU  - Risk, for Genetic
AU  - Pröbstel, Anne-Katrin
AU  - Martinez-Martinez, Pilar
TI  - Autoantibodies against myelin oligodendrocyte glycoprotein in a subgroup of patients with psychotic symptoms.
JO  - Frontiers in neurology
VL  - 16
SN  - 1664-2295
CY  - Lausanne
PB  - Frontiers Research Foundation
M1  - DZNE-2025-00901
SP  - 1593042
PY  - 2025
AB  - The presence of autoantibodies against myelin oligodendrocyte glycoprotein (MOG) is a hallmark of MOG antibody-associated disease (MOGAD), a recently defined demyelinating disease entity presenting with core clinical features of optic neuritis, myelitis, and acute disseminated encephalomyelitis. Although MOG antibodies have also been described in a small number of patients with other conditions, including mental disorders, their prevalence and clinical specificity in patients with isolated psychotic symptoms remain unclear. Here, we screened sera from 262 patients with at least one psychotic episode and 166 control subjects for the presence of MOG antibodies of the immunoglobulin G (IgG) isotype with a live cell-based assay. Serum reactivity to additional antigens was assessed by immunohistochemistry. Four patients, representing 1.5
KW  - autoantibodies (Other)
KW  - mental disorders (Other)
KW  - myelin oligodendrocyte glycoprotein antibody-associated disease (Other)
KW  - neuroinflammation (Other)
KW  - psychiatry (Other)
KW  - psychosis (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40757033
C2  - pmc:PMC12316182
DO  - DOI:10.3389/fneur.2025.1593042
UR  - https://pub.dzne.de/record/280223
ER  -