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@ARTICLE{vandeBurgt:280223,
      author       = {van de Burgt, Nikita A and Kulsvehagen, Laila and
                      Mané-Damas, Marina and Lutz, Luc and Lecourt,
                      Anne-Catherine and Monserrat, Clara and Vinke, Anita M and
                      Küçükali, Cem I and Zong, Shenghua and Hoffmann, Carolin
                      and González-Vioque, Emiliano and Arango, Celso and
                      Leibold, Nicole K and Losen, Mario and Molenaar, Peter C and
                      Tüzün, Erdem and van Beveren, Nico J M and Mané, Anna and
                      Rouhl, Rob P W and van Amelsvoort, Therese A M J and Risk,
                      for Genetic and Pröbstel, Anne-Katrin and
                      Martinez-Martinez, Pilar},
      collaboration = {Psychosis, Outcome of},
      title        = {{A}utoantibodies against myelin oligodendrocyte
                      glycoprotein in a subgroup of patients with psychotic
                      symptoms.},
      journal      = {Frontiers in neurology},
      volume       = {16},
      issn         = {1664-2295},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {DZNE-2025-00901},
      pages        = {1593042},
      year         = {2025},
      abstract     = {The presence of autoantibodies against myelin
                      oligodendrocyte glycoprotein (MOG) is a hallmark of MOG
                      antibody-associated disease (MOGAD), a recently defined
                      demyelinating disease entity presenting with core clinical
                      features of optic neuritis, myelitis, and acute disseminated
                      encephalomyelitis. Although MOG antibodies have also been
                      described in a small number of patients with other
                      conditions, including mental disorders, their prevalence and
                      clinical specificity in patients with isolated psychotic
                      symptoms remain unclear. Here, we screened sera from 262
                      patients with at least one psychotic episode and 166 control
                      subjects for the presence of MOG antibodies of the
                      immunoglobulin G (IgG) isotype with a live cell-based assay.
                      Serum reactivity to additional antigens was assessed by
                      immunohistochemistry. Four patients, representing $1.5\%$ of
                      the patient cohort, and one control individual,
                      representing. $0.6\%$ of the healthy control cohort, were
                      seropositive for MOG-IgG antibodies. Of the four MOG-IgG
                      seropositive patients, three experienced visual
                      hallucinations. Overall, MOG antibodies were detected at a
                      low frequency in patients with psychotic episodes. While we
                      cannot exclude the possibility of false-positive results or
                      seroconversion due to secondary myelin damage, the
                      association with visual hallucinations in three out of four
                      MOG-IgG seropositive patients may point toward an underlying
                      autoimmune etiology.},
      keywords     = {autoantibodies (Other) / mental disorders (Other) / myelin
                      oligodendrocyte glycoprotein antibody-associated disease
                      (Other) / neuroinflammation (Other) / psychiatry (Other) /
                      psychosis (Other)},
      cin          = {AG Pröbstel},
      ddc          = {610},
      cid          = {I:(DE-2719)1013045},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40757033},
      pmc          = {pmc:PMC12316182},
      doi          = {10.3389/fneur.2025.1593042},
      url          = {https://pub.dzne.de/record/280223},
}