000280910 001__ 280910
000280910 005__ 20250907001930.0
000280910 0247_ $$2doi$$a10.1038/s41531-025-01128-3
000280910 0247_ $$2pmid$$apmid:40877314
000280910 0247_ $$2altmetric$$aaltmetric:180740337
000280910 037__ $$aDZNE-2025-00993
000280910 041__ $$aEnglish
000280910 082__ $$a610
000280910 1001_ $$aKübler-Weller, Dorothee$$b0
000280910 245__ $$aPredicting cognition after subthalamic Deep Brain Stimulation in Parkinson's Disease.
000280910 260__ $$a[London]$$bSpringer Nature$$c2025
000280910 3367_ $$2DRIVER$$aarticle
000280910 3367_ $$2DataCite$$aOutput Types/Journal article
000280910 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1756474326_5450
000280910 3367_ $$2BibTeX$$aARTICLE
000280910 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000280910 3367_ $$00$$2EndNote$$aJournal Article
000280910 520__ $$aCognitive deficits have a high impact on quality of life in Parkinson's disease (PD). This study takes into account the multifaceted etiology of cognition to estimate the cognitive outcome after deep brain stimulation (DBS) surgery in PD. Clinical, neuropsychological, perioperative, neuroimaging- and laboratory-based risk factors for cognitive dysfunction were prospectively assessed prior to surgery in 57 patients (21 female; age 60.2 ± 8.2; disease duration 10.5 ± 5.9 years, preregistered 9 June 2019 at clinicaltrials.gov, NCT03982953). Elastic net regularized regression and leave-one-out cross-validation were used to fit a multivariable model with the Montréal Cognitive Assessment (MoCA) change one year after surgery as primary outcome. The backward span had the most robust association with the cognitive outcome (rho = 0.499, p < 0.001**; c = 0.302). We propose a post-hoc prediction model for cognition based on the baseline MoCA and backward span (R² = 0.50). After clinical validation, our short and easily applicable prediction model could improve informed therapeutic decision making.
000280910 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000280910 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000280910 7001_ $$aStuke, Heiner$$b1
000280910 7001_ $$aAstalosch, Melanie$$b2
000280910 7001_ $$aMartins Ribeiro, Luísa$$b3
000280910 7001_ $$aLandfried, Elias$$b4
000280910 7001_ $$aSchneider, Gerd-Helge$$b5
000280910 7001_ $$aFaust, Katharina$$b6
000280910 7001_ $$aKrause, Patricia$$b7
000280910 7001_ $$aRoediger, Jan$$b8
000280910 7001_ $$aHaufe, Stefan$$b9
000280910 7001_ $$aMousavi, Mahta$$b10
000280910 7001_ $$aAl-Fatly, Bassam$$b11
000280910 7001_ $$aSpies, Claudia$$b12
000280910 7001_ $$aBorchers, Friedrich$$b13
000280910 7001_ $$0P:(DE-2719)2811089$$aKühn, Andrea A$$b14$$eLast author$$udzne
000280910 773__ $$0PERI:(DE-600)2819218-7$$a10.1038/s41531-025-01128-3$$gVol. 11, no. 1, p. 265$$n1$$p265$$tnpj Parkinson's Disease$$v11$$x2373-8057$$y2025
000280910 8564_ $$uhttps://pub.dzne.de/record/280910/files/DZNE-2025-00993.pdf$$yOpenAccess
000280910 8564_ $$uhttps://pub.dzne.de/record/280910/files/DZNE-2025-00993%20SUP.pdf
000280910 8564_ $$uhttps://pub.dzne.de/record/280910/files/DZNE-2025-00993%20SUP.pdf?subformat=pdfa$$xpdfa
000280910 8564_ $$uhttps://pub.dzne.de/record/280910/files/DZNE-2025-00993.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000280910 909CO $$ooai:pub.dzne.de:280910$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000280910 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811089$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b14$$kDZNE
000280910 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000280910 9141_ $$y2025
000280910 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2024-12-11
000280910 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2024-12-11
000280910 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2024-12-11
000280910 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000280910 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNPJ PARKINSONS DIS : 2022$$d2024-12-11
000280910 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2024-04-10T15:43:48Z
000280910 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2024-04-10T15:43:48Z
000280910 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2024-12-11
000280910 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2024-12-11
000280910 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2024-12-11
000280910 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000280910 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Anonymous peer review$$d2024-04-10T15:43:48Z
000280910 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2024-12-11
000280910 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bNPJ PARKINSONS DIS : 2022$$d2024-12-11
000280910 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2024-12-11
000280910 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2024-12-11
000280910 9201_ $$0I:(DE-2719)5000008$$kAG Kühn$$lMovement Disorders (Parkinson's disease, Dystonia)$$x0
000280910 980__ $$ajournal
000280910 980__ $$aVDB
000280910 980__ $$aUNRESTRICTED
000280910 980__ $$aI:(DE-2719)5000008
000280910 9801_ $$aFullTexts