Journal Article

DZNE-2025-00993

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Predicting cognition after subthalamic Deep Brain Stimulation in Parkinson's Disease.

Kübler-Weller, D. ; Stuke, H. ; Astalosch, M. ; Martins Ribeiro, L. ; Landfried, E. ; Schneider, G.-H. ; Faust, K. ; Krause, P. ; Roediger, J. ; Haufe, S. ; Mousavi, M. ; Al-Fatly, B. ; Spies, C. ; Borchers, F. ; Kühn, A. A. (Last author)DZNE*

2025
Springer Nature [London]

This record in other databases:    

Please use a persistent id in citations: doi:10.1038/s41531-025-01128-3

Abstract: Cognitive deficits have a high impact on quality of life in Parkinson's disease (PD). This study takes into account the multifaceted etiology of cognition to estimate the cognitive outcome after deep brain stimulation (DBS) surgery in PD. Clinical, neuropsychological, perioperative, neuroimaging- and laboratory-based risk factors for cognitive dysfunction were prospectively assessed prior to surgery in 57 patients (21 female; age 60.2 ± 8.2; disease duration 10.5 ± 5.9 years, preregistered 9 June 2019 at clinicaltrials.gov, NCT03982953). Elastic net regularized regression and leave-one-out cross-validation were used to fit a multivariable model with the Montréal Cognitive Assessment (MoCA) change one year after surgery as primary outcome. The backward span had the most robust association with the cognitive outcome (rho = 0.499, p < 0.001**; c = 0.302). We propose a post-hoc prediction model for cognition based on the baseline MoCA and backward span (R² = 0.50). After clinical validation, our short and easily applicable prediction model could improve informed therapeutic decision making.

---

Contributing Institute(s):

1. Movement Disorders (Parkinson's disease, Dystonia) (AG Kühn)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2025

---

Database coverage:
; ; ; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---