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000280935 005__ 20250918102642.0
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000280935 037__ $$aDZNE-2025-01018
000280935 1001_ $$0P:(DE-2719)9002244$$aRavichandran, Kishore Aravind$$b0$$udzne
000280935 245__ $$aInflammasome and neurodegenerative diseases
000280935 260__ $$bElsevier$$c2023
000280935 29510 $$aInflammasome Biology / Ravichandran, Kishore Aravind ; : Elsevier, 2023, ; ISBN: 9780323918022 ; doi:10.1016/B978-0-323-91802-2.00029-3
000280935 300__ $$a291 - 326
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000280935 520__ $$aInflammasome biology has been implicated in several diseases that exhibit underlying inflammatory processes. Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, and Amyotrophic lateral sclerosis are known for chronic neuroinflammation in the brain. Recent studies have shown that inflammasome activation accelerates the neurodegeneration process in these diseases by initiating an inflammatory chain reaction. Understanding the biology and mechanism of inflammasome in these diseases is crucial to devise novel treatment strategies. Here, we present evidence for inflammasome activation, particularly NLRP3, in these neurodegenerative diseases. Additionally, we highlight the current modulation strategies used to ameliorate inflammasome activation and subsequently impacting disease progression.
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000280935 7001_ $$0P:(DE-2719)2000008$$aHeneka, Michael$$b1
000280935 773__ $$a10.1016/B978-0-323-91802-2.00029-3
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000280935 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9002244$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000280935 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000008$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
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000280935 9201_ $$0I:(DE-2719)1011303$$kAG Heneka$$lNeuroinflammation, Biomarker$$x0
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