Contribution to a book

DZNE-2025-01018

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Inflammasome and neurodegenerative diseases

Ravichandran, K. A.DZNE* ; Heneka, M.DZNE*

2023
Elsevier

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Please use a persistent id in citations: doi:10.1016/B978-0-323-91802-2.00029-3

Abstract: Inflammasome biology has been implicated in several diseases that exhibit underlying inflammatory processes. Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, and Amyotrophic lateral sclerosis are known for chronic neuroinflammation in the brain. Recent studies have shown that inflammasome activation accelerates the neurodegeneration process in these diseases by initiating an inflammatory chain reaction. Understanding the biology and mechanism of inflammasome in these diseases is crucial to devise novel treatment strategies. Here, we present evidence for inflammasome activation, particularly NLRP3, in these neurodegenerative diseases. Additionally, we highlight the current modulation strategies used to ameliorate inflammasome activation and subsequently impacting disease progression.

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Contributing Institute(s):

1. Neuroinflammation, Biomarker (AG Heneka)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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