001     280935
005     20250918102642.0
024 7 _ |a 10.1016/B978-0-323-91802-2.00029-3
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037 _ _ |a DZNE-2025-01018
100 1 _ |a Ravichandran, Kishore Aravind
|0 P:(DE-2719)9002244
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|u dzne
245 _ _ |a Inflammasome and neurodegenerative diseases
260 _ _ |c 2023
|b Elsevier
295 1 0 |a Inflammasome Biology / Ravichandran, Kishore Aravind ; : Elsevier, 2023, ; ISBN: 9780323918022 ; doi:10.1016/B978-0-323-91802-2.00029-3
300 _ _ |a 291 - 326
336 7 _ |a BOOK_CHAPTER
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336 7 _ |a Contribution to a book
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520 _ _ |a Inflammasome biology has been implicated in several diseases that exhibit underlying inflammatory processes. Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, and Amyotrophic lateral sclerosis are known for chronic neuroinflammation in the brain. Recent studies have shown that inflammasome activation accelerates the neurodegeneration process in these diseases by initiating an inflammatory chain reaction. Understanding the biology and mechanism of inflammasome in these diseases is crucial to devise novel treatment strategies. Here, we present evidence for inflammasome activation, particularly NLRP3, in these neurodegenerative diseases. Additionally, we highlight the current modulation strategies used to ameliorate inflammasome activation and subsequently impacting disease progression.
536 _ _ |a 353 - Clinical and Health Care Research (POF4-353)
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588 _ _ |a Dataset connected to CrossRef Book
700 1 _ |a Heneka, Michael
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773 _ _ |a 10.1016/B978-0-323-91802-2.00029-3
909 C O |o oai:pub.dzne.de:280935
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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920 1 _ |0 I:(DE-2719)1011303
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980 _ _ |a contb
980 _ _ |a VDB
980 _ _ |a I:(DE-2719)1011303
980 _ _ |a UNRESTRICTED


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