TY  - JOUR
AU  - Flaskamp, Lavinia
AU  - Prechtl, Monica
AU  - Scheck, Annkathrin
AU  - Hu, Wenbo
AU  - Ried, Christine
AU  - Kislinger, Georg
AU  - Simons, Mikael
AU  - Krug, Anne B.
AU  - Kranich, Jan
AU  - Brocker, Thomas
TI  - Assessing Extracellular Vesicle Turnover In Vivo Using Highly Sensitive Phosphatidylserine‐Binding Reagents
JO  - Advanced science
VL  - Advance online publication
SN  - 2198-3844
CY  - Weinheim
PB  - Wiley-VCH
M1  - DZNE-2025-01089
SP  - e07624
PY  - 2025
AB  - Extracellular vesicles (EVs) are emerging as crucial players in cell communication and hold great promise as biomarkers and therapeutic tools. However, their diversity makes it challenging to detect, classify, and utilize them effectively, which limits their clinical applicability. A key challenge is the lack of reliable markers to identify EVs consistently. In this study, a novel high-affinity phosphatidylserine (PS)-binding reagent is introduced for EV analysis. PS is known as a marker of apoptotic cells and activated platelets, but its presence on EVs is debated due to variations in lipid composition. By comparing multiple PS-binding reagents, including MFG-E8 derivatives and Annexin V, it is demonstrated that ≈90
LB  - PUB:(DE-HGF)16
C6  - pmid:40817753
DO  - DOI:10.1002/advs.202507624
UR  - https://pub.dzne.de/record/281188
ER  -