TY  - JOUR
AU  - Cesari, Matteo
AU  - Brink-Kjaer, Andreas
AU  - During, Emmanuel
AU  - Ganglberger, Wolfgang
AU  - Gnarra, Oriella
AU  - Huang, Bei
AU  - Sommerauer, Michael
AU  - Ratti, Pietro Luca
AU  - Rechichi, Irene
AU  - Wing, Yun Kwok
AU  - Stefani, Ambra
TI  - Isolated REM Sleep Behaviour Disorder-Is Screening Possible?
JO  - Journal of sleep research
VL  - 34
IS  - 5
SN  - 0962-1105
CY  - Oxford [u.a.]
PB  - Wiley-Blackwell
M1  - DZNE-2025-01102
SP  - e70109
PY  - 2025
AB  - Rapid eye movement (REM) sleep behaviour disorder (RBD) is a parasomnia characterised by the loss of muscle atonia during REM sleep and dream-enacting behaviours. In its isolated form (iRBD) it is widely recognised as an early stage of alpha-synucleinopathies. Early identification of patients with iRBD allows for timely interventions, risk mitigation and potential inclusion in clinical trials aimed at disease modification. Effective screening tools, including questionnaires, automatic analyses of video-polysomnography, actigraphy, nearables and biological markers, can facilitate diagnosis and monitoring. Incorporating routine screening into clinical practice may enhance early detection and improve long-term patient outcomes. This manuscript presents the latest developments in screening tools for the identification of patients with iRBD and discusses their advantages and drawbacks, highlighting paths for future research and applications.
KW  - Humans
KW  - REM Sleep Behavior Disorder: diagnosis
KW  - Polysomnography
KW  - Actigraphy
KW  - Surveys and Questionnaires
KW  - Mass Screening: methods
KW  - RBD (Other)
KW  - iRBD (Other)
KW  - prodromal alpha‐synucleinopathy (Other)
KW  - screening tool (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40461179
C2  - pmc:PMC12426715
DO  - DOI:10.1111/jsr.70109
UR  - https://pub.dzne.de/record/281355
ER  -