Journal Article (Review Article)

DZNE-2025-01102

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Isolated REM Sleep Behaviour Disorder-Is Screening Possible?

Cesari, M. ; Brink-Kjaer, A. ; During, E. ; Ganglberger, W. ; Gnarra, O. ; Huang, B. ; Sommerauer, M.DZNE* ; Ratti, P. L. ; Rechichi, I. ; Wing, Y. K. ; Stefani, A.

2025
Wiley-Blackwell Oxford [u.a.]

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Please use a persistent id in citations: doi:10.1111/jsr.70109

Abstract: Rapid eye movement (REM) sleep behaviour disorder (RBD) is a parasomnia characterised by the loss of muscle atonia during REM sleep and dream-enacting behaviours. In its isolated form (iRBD) it is widely recognised as an early stage of alpha-synucleinopathies. Early identification of patients with iRBD allows for timely interventions, risk mitigation and potential inclusion in clinical trials aimed at disease modification. Effective screening tools, including questionnaires, automatic analyses of video-polysomnography, actigraphy, nearables and biological markers, can facilitate diagnosis and monitoring. Incorporating routine screening into clinical practice may enhance early detection and improve long-term patient outcomes. This manuscript presents the latest developments in screening tools for the identification of patients with iRBD and discusses their advantages and drawbacks, highlighting paths for future research and applications.

Keyword(s): Humans (MeSH) ; REM Sleep Behavior Disorder: diagnosis (MeSH) ; Polysomnography (MeSH) ; Actigraphy (MeSH) ; Surveys and Questionnaires (MeSH) ; Mass Screening: methods (MeSH) ; RBD ; iRBD ; prodromal alpha‐synucleinopathy ; screening tool

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Contributing Institute(s):

1. Vascular Neurology (AG Petzold)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2025

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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