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@ARTICLE{Cesari:281355,
      author       = {Cesari, Matteo and Brink-Kjaer, Andreas and During,
                      Emmanuel and Ganglberger, Wolfgang and Gnarra, Oriella and
                      Huang, Bei and Sommerauer, Michael and Ratti, Pietro Luca
                      and Rechichi, Irene and Wing, Yun Kwok and Stefani, Ambra},
      title        = {{I}solated {REM} {S}leep {B}ehaviour {D}isorder-{I}s
                      {S}creening {P}ossible?},
      journal      = {Journal of sleep research},
      volume       = {34},
      number       = {5},
      issn         = {0962-1105},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2025-01102},
      pages        = {e70109},
      year         = {2025},
      abstract     = {Rapid eye movement (REM) sleep behaviour disorder (RBD) is
                      a parasomnia characterised by the loss of muscle atonia
                      during REM sleep and dream-enacting behaviours. In its
                      isolated form (iRBD) it is widely recognised as an early
                      stage of alpha-synucleinopathies. Early identification of
                      patients with iRBD allows for timely interventions, risk
                      mitigation and potential inclusion in clinical trials aimed
                      at disease modification. Effective screening tools,
                      including questionnaires, automatic analyses of
                      video-polysomnography, actigraphy, nearables and biological
                      markers, can facilitate diagnosis and monitoring.
                      Incorporating routine screening into clinical practice may
                      enhance early detection and improve long-term patient
                      outcomes. This manuscript presents the latest developments
                      in screening tools for the identification of patients with
                      iRBD and discusses their advantages and drawbacks,
                      highlighting paths for future research and applications.},
      subtyp        = {Review Article},
      keywords     = {Humans / REM Sleep Behavior Disorder: diagnosis /
                      Polysomnography / Actigraphy / Surveys and Questionnaires /
                      Mass Screening: methods / RBD (Other) / iRBD (Other) /
                      prodromal alpha‐synucleinopathy (Other) / screening tool
                      (Other)},
      cin          = {AG Petzold},
      ddc          = {610},
      cid          = {I:(DE-2719)1013020},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40461179},
      pmc          = {pmc:PMC12426715},
      doi          = {10.1111/jsr.70109},
      url          = {https://pub.dzne.de/record/281355},
}