% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Segen:281783,
      author       = {Segen, Vladislava and Stangl, Matthias and Shine, Jonathan
                      and Wolbers, Thomas},
      title        = {{A}ltered {C}oding of {E}nvironmental {B}oundaries in
                      {H}uman {A}ging: {A}n f{MRI} {S}tudy},
      journal      = {Hippocampus},
      volume       = {35},
      number       = {6},
      issn         = {1050-9631},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {DZNE-2025-01176},
      pages        = {e70044},
      year         = {2025},
      abstract     = {Aging is associated with changes in spatial memory and
                      navigation, yet the mechanisms underlying these changes are
                      not yet fully understood. Environmental boundaries are among
                      the most salient and reliable spatial cues, supporting both
                      spatial memory and orientation. Here, we investigated how
                      aging affects the use and the neural representation of
                      boundary information during a virtual object location memory
                      task. Healthy young and older adults navigated a square
                      virtual environment while undergoing functional magnetic
                      resonance imaging, allowing us to assess moment-to-moment
                      encoding of distance to environmental boundaries in the
                      entorhinal cortex and subiculum. Behaviorally, both age
                      groups showed more accurate memory for objects located near
                      boundaries, but this effect was amplified in older adults,
                      whose spatial precision declined more steeply with
                      increasing distance from boundaries. Older adults also
                      exhibited a stronger bias to recall objects closer to
                      boundaries. Analysis of navigation behavior revealed that
                      older adults followed boundary-oriented paths regardless of
                      target location, whereas young adults flexibly adapted their
                      navigation based on spatial context. Neurally, older
                      adults—but not young adults—showed significant
                      blood-oxygen-level-dependent modulation by boundary distance
                      in the entorhinal cortex and subiculum, with activity
                      decreasing as participants moved farther from boundaries.
                      This effect was most pronounced in low-performing older
                      adults and was associated with stronger behavioral boundary
                      bias, suggesting a maladaptive reliance on proximity-based
                      cues. Together, our results provide converging behavioral
                      and neural evidence that aging alters the use and
                      representation of boundary information, with downstream
                      effects on spatial memory. Altered boundary processing may
                      represent a key mechanism contributing to age-related
                      declines in spatial cognition.},
      cin          = {AG Wolbers},
      ddc          = {610},
      cid          = {I:(DE-2719)1310002},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1002/hipo.70044},
      url          = {https://pub.dzne.de/record/281783},
}