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001     281783
005     20260105130604.0
024 7 _ |a pmid:41099159
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024 7 _ |a 10.1002/hipo.70044
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024 7 _ |a 1050-9631
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024 7 _ |a 1098-1063
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037 _ _ |a DZNE-2025-01176
082 _ _ |a 610
100 1 _ |a Segen, Vladislava
|0 P:(DE-2719)9001409
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245 _ _ |a Altered Coding of Environmental Boundaries in Human Aging: An fMRI Study
260 _ _ |a New York, NY [u.a.]
|c 2025
|b Wiley
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520 _ _ |a Aging is associated with changes in spatial memory and navigation, yet the mechanisms underlying these changes are not yet fully understood. Environmental boundaries are among the most salient and reliable spatial cues, supporting both spatial memory and orientation. Here, we investigated how aging affects the use and the neural representation of boundary information during a virtual object location memory task. Healthy young and older adults navigated a square virtual environment while undergoing functional magnetic resonance imaging, allowing us to assess moment-to-moment encoding of distance to environmental boundaries in the entorhinal cortex and subiculum. Behaviorally, both age groups showed more accurate memory for objects located near boundaries, but this effect was amplified in older adults, whose spatial precision declined more steeply with increasing distance from boundaries. Older adults also exhibited a stronger bias to recall objects closer to boundaries. Analysis of navigation behavior revealed that older adults followed boundary-oriented paths regardless of target location, whereas young adults flexibly adapted their navigation based on spatial context. Neurally, older adults-but not young adults-showed significant blood-oxygen-level-dependent modulation by boundary distance in the entorhinal cortex and subiculum, with activity decreasing as participants moved farther from boundaries. This effect was most pronounced in low-performing older adults and was associated with stronger behavioral boundary bias, suggesting a maladaptive reliance on proximity-based cues. Together, our results provide converging behavioral and neural evidence that aging alters the use and representation of boundary information, with downstream effects on spatial memory. Altered boundary processing may represent a key mechanism contributing to age-related declines in spatial cognition.
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650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Aging: physiology
|2 MeSH
650 _ 2 |a Aging: psychology
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Young Adult
|2 MeSH
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Spatial Navigation: physiology
|2 MeSH
650 _ 2 |a Entorhinal Cortex: physiology
|2 MeSH
650 _ 2 |a Entorhinal Cortex: diagnostic imaging
|2 MeSH
650 _ 2 |a Spatial Memory: physiology
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Brain Mapping
|2 MeSH
650 _ 2 |a Hippocampus: physiology
|2 MeSH
650 _ 2 |a Hippocampus: diagnostic imaging
|2 MeSH
650 _ 2 |a Space Perception: physiology
|2 MeSH
650 _ 2 |a Virtual Reality
|2 MeSH
650 _ 2 |a Environment
|2 MeSH
700 1 _ |a Stangl, Matthias
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700 1 _ |a Shine, Jonathan
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700 1 _ |a Wolbers, Thomas
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773 _ _ |a 10.1002/hipo.70044
|g Vol. 35, no. 6, p. e70044
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