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000281842 1001_ $$00000-0002-6585-9532$$aMan, Kevin$$b0
000281842 245__ $$aStem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine.
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000281842 520__ $$aTissue-resident memory T (TRM) cells provide localized immunity against intracellular pathogens and cancer. Upon antigen reencounter, TRM cells differentiate into effector cells while also giving rise to another generation of memory cells. Here, we show that intestinal TRM cells that express the transcriptional regulators TCF1 or ID3 exhibit stem-like memory properties and are endowed with a superior capacity to regenerate effector and memory T cells after pathogen reencounter. Ablation of TCF1 using a TRM cell-specific mouse model resulted in impaired formation of intestinal TRM cells, altered their transcriptional heterogeneity, and increased their differentiation into tissue-confined and recirculating CX3CR1+ effector cells during recall. TGF-β and retinoic acid were required for formation and survival of TCF1- and ID3-expressing TRM cells and restrained their differentiation into CX3CR1+ effector cells during reinfection. Thus, stem-like cells control the quality and recall capacity of TRM cells, thereby contributing to anamnestic memory responses.
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000281842 650_7 $$2NLM Chemicals$$aHepatocyte Nuclear Factor 1-alpha
000281842 650_7 $$2NLM Chemicals$$aHnf1a protein, mouse
000281842 650_7 $$0135845-89-5$$2NLM Chemicals$$aIdb3 protein, mouse
000281842 650_7 $$2NLM Chemicals$$aInhibitor of Differentiation Proteins
000281842 650_7 $$2NLM Chemicals$$aCX3C Chemokine Receptor 1
000281842 650_7 $$2NLM Chemicals$$aT Cell Transcription Factor 1
000281842 650_2 $$2MeSH$$aAnimals
000281842 650_2 $$2MeSH$$aImmunologic Memory: immunology
000281842 650_2 $$2MeSH$$aMemory T Cells: immunology
000281842 650_2 $$2MeSH$$aMice
000281842 650_2 $$2MeSH$$aMice, Inbred C57BL
000281842 650_2 $$2MeSH$$aIntestines: immunology
000281842 650_2 $$2MeSH$$aHepatocyte Nuclear Factor 1-alpha: genetics
000281842 650_2 $$2MeSH$$aHepatocyte Nuclear Factor 1-alpha: immunology
000281842 650_2 $$2MeSH$$aCell Differentiation: immunology
000281842 650_2 $$2MeSH$$aInhibitor of Differentiation Proteins: immunology
000281842 650_2 $$2MeSH$$aInhibitor of Differentiation Proteins: genetics
000281842 650_2 $$2MeSH$$aCX3C Chemokine Receptor 1
000281842 650_2 $$2MeSH$$aStem Cells: immunology
000281842 650_2 $$2MeSH$$aMice, Knockout
000281842 650_2 $$2MeSH$$aT Cell Transcription Factor 1: genetics
000281842 650_2 $$2MeSH$$aT Cell Transcription Factor 1: immunology
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000281842 7001_ $$00000-0002-2865-3375$$aDuarte da Silva, Vinicius A$$b1
000281842 7001_ $$00000-0002-1459-751X$$aPotemkin, Nikita$$b2
000281842 7001_ $$00000-0002-6359-485X$$aGabriel, Sarah S$$b3
000281842 7001_ $$00009-0008-3166-4228$$aMason, Teisha$$b4
000281842 7001_ $$0P:(DE-2719)9000539$$aElmzzahi, Tarek$$b5
000281842 7001_ $$00000-0003-3477-0727$$aDe Lima Moreira, Marcela$$b6
000281842 7001_ $$00000-0003-1825-6154$$aSu, Chun-Hsi$$b7
000281842 7001_ $$00000-0002-8496-6632$$aMackay, Laura$$b8
000281842 7001_ $$0P:(DE-2719)2812219$$aBeyer, Marc D$$b9
000281842 7001_ $$00000-0001-5270-0605$$aSchröder, Jan$$b10
000281842 7001_ $$00000-0001-6986-127X$$aGasteiger, Georg$$b11
000281842 7001_ $$00000-0002-6312-6968$$aKallies, Axel$$b12
000281842 773__ $$0PERI:(DE-600)2862556-0$$a10.1126/sciimmunol.adw1992$$gVol. 10, no. 112, p. eadw1992$$n112$$peadw1992$$tScience immunology$$v10$$x2470-9468$$y2025
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