Journal Article

DZNE-2025-01221

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine.

Man, K. ; Duarte da Silva, V. A. ; Potemkin, N. ; Gabriel, S. S. ; Mason, T. ; Elmzzahi, T.DZNE* ; De Lima Moreira, M. ; Su, C.-H. ; Mackay, L. ; Beyer, M. D.DZNE* ; Schröder, J. ; Gasteiger, G. ; Kallies, A.

2025
AAAS Washington, DC

This record in other databases:    

Please use a persistent id in citations: doi:10.1126/sciimmunol.adw1992

Abstract: Tissue-resident memory T (TRM) cells provide localized immunity against intracellular pathogens and cancer. Upon antigen reencounter, TRM cells differentiate into effector cells while also giving rise to another generation of memory cells. Here, we show that intestinal TRM cells that express the transcriptional regulators TCF1 or ID3 exhibit stem-like memory properties and are endowed with a superior capacity to regenerate effector and memory T cells after pathogen reencounter. Ablation of TCF1 using a TRM cell-specific mouse model resulted in impaired formation of intestinal TRM cells, altered their transcriptional heterogeneity, and increased their differentiation into tissue-confined and recirculating CX3CR1+ effector cells during recall. TGF-β and retinoic acid were required for formation and survival of TCF1- and ID3-expressing TRM cells and restrained their differentiation into CX3CR1+ effector cells during reinfection. Thus, stem-like cells control the quality and recall capacity of TRM cells, thereby contributing to anamnestic memory responses.

Keyword(s): Animals (MeSH) ; Immunologic Memory: immunology (MeSH) ; Memory T Cells: immunology (MeSH) ; Mice (MeSH) ; Mice, Inbred C57BL (MeSH) ; Intestines: immunology (MeSH) ; Hepatocyte Nuclear Factor 1-alpha: genetics (MeSH) ; Hepatocyte Nuclear Factor 1-alpha: immunology (MeSH) ; Cell Differentiation: immunology (MeSH) ; Inhibitor of Differentiation Proteins: immunology (MeSH) ; Inhibitor of Differentiation Proteins: genetics (MeSH) ; CX3C Chemokine Receptor 1 (MeSH) ; Stem Cells: immunology (MeSH) ; Mice, Knockout (MeSH) ; T Cell Transcription Factor 1: genetics (MeSH) ; T Cell Transcription Factor 1: immunology (MeSH) ; Hepatocyte Nuclear Factor 1-alpha ; Hnf1a protein, mouse ; Idb3 protein, mouse ; Inhibitor of Differentiation Proteins ; CX3C Chemokine Receptor 1 ; T Cell Transcription Factor 1

---

Contributing Institute(s):

1. Immunogenomics and Neurodegeneration (AG Beyer)
2. Platform for Single Cell Genomics and Epigenomics (PRECISE)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)
2. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Experiment(s):

1. Platform for Single Cell Genomics and Epigenomics at DZNE University of Bonn

Appears in the scientific report 2025

---

Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Essential Science Indicators ; IF >= 20 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---