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@ARTICLE{Man:281842,
      author       = {Man, Kevin and Duarte da Silva, Vinicius A and Potemkin,
                      Nikita and Gabriel, Sarah S and Mason, Teisha and Elmzzahi,
                      Tarek and De Lima Moreira, Marcela and Su, Chun-Hsi and
                      Mackay, Laura and Beyer, Marc D and Schröder, Jan and
                      Gasteiger, Georg and Kallies, Axel},
      title        = {{S}tem-like tissue-resident memory {T} cells control
                      functional heterogeneity and reactivation of {T} cell memory
                      in the intestine.},
      journal      = {Science immunology},
      volume       = {10},
      number       = {112},
      issn         = {2470-9468},
      address      = {Washington, DC},
      publisher    = {AAAS},
      reportid     = {DZNE-2025-01221},
      pages        = {eadw1992},
      year         = {2025},
      abstract     = {Tissue-resident memory T (TRM) cells provide localized
                      immunity against intracellular pathogens and cancer. Upon
                      antigen reencounter, TRM cells differentiate into effector
                      cells while also giving rise to another generation of memory
                      cells. Here, we show that intestinal TRM cells that express
                      the transcriptional regulators TCF1 or ID3 exhibit stem-like
                      memory properties and are endowed with a superior capacity
                      to regenerate effector and memory T cells after pathogen
                      reencounter. Ablation of TCF1 using a TRM cell-specific
                      mouse model resulted in impaired formation of intestinal TRM
                      cells, altered their transcriptional heterogeneity, and
                      increased their differentiation into tissue-confined and
                      recirculating CX3CR1+ effector cells during recall. TGF-β
                      and retinoic acid were required for formation and survival
                      of TCF1- and ID3-expressing TRM cells and restrained their
                      differentiation into CX3CR1+ effector cells during
                      reinfection. Thus, stem-like cells control the quality and
                      recall capacity of TRM cells, thereby contributing to
                      anamnestic memory responses.},
      keywords     = {Animals / Immunologic Memory: immunology / Memory T Cells:
                      immunology / Mice / Mice, Inbred C57BL / Intestines:
                      immunology / Hepatocyte Nuclear Factor 1-alpha: genetics /
                      Hepatocyte Nuclear Factor 1-alpha: immunology / Cell
                      Differentiation: immunology / Inhibitor of Differentiation
                      Proteins: immunology / Inhibitor of Differentiation
                      Proteins: genetics / CX3C Chemokine Receptor 1 / Stem Cells:
                      immunology / Mice, Knockout / T Cell Transcription Factor 1:
                      genetics / T Cell Transcription Factor 1: immunology /
                      Hepatocyte Nuclear Factor 1-alpha (NLM Chemicals) / Hnf1a
                      protein, mouse (NLM Chemicals) / Idb3 protein, mouse (NLM
                      Chemicals) / Inhibitor of Differentiation Proteins (NLM
                      Chemicals) / CX3C Chemokine Receptor 1 (NLM Chemicals) / T
                      Cell Transcription Factor 1 (NLM Chemicals)},
      cin          = {AG Beyer / PRECISE},
      ddc          = {610},
      cid          = {I:(DE-2719)1013035 / I:(DE-2719)1013031},
      pnm          = {351 - Brain Function (POF4-351) / 352 - Disease Mechanisms
                      (POF4-352)},
      pid          = {G:(DE-HGF)POF4-351 / G:(DE-HGF)POF4-352},
      experiment   = {EXP:(DE-2719)PRECISE-20190321},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41171881},
      doi          = {10.1126/sciimmunol.adw1992},
      url          = {https://pub.dzne.de/record/281842},
}