Home > Publications Database > Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine. > print

001     281842
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024 7 _ |a 10.1126/sciimmunol.adw1992
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037 _ _ |a DZNE-2025-01221
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082 _ _ |a 610
100 1 _ |a Man, Kevin
|0 0000-0002-6585-9532
|b 0
245 _ _ |a Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine.
260 _ _ |a Washington, DC
|c 2025
|b AAAS
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520 _ _ |a Tissue-resident memory T (TRM) cells provide localized immunity against intracellular pathogens and cancer. Upon antigen reencounter, TRM cells differentiate into effector cells while also giving rise to another generation of memory cells. Here, we show that intestinal TRM cells that express the transcriptional regulators TCF1 or ID3 exhibit stem-like memory properties and are endowed with a superior capacity to regenerate effector and memory T cells after pathogen reencounter. Ablation of TCF1 using a TRM cell-specific mouse model resulted in impaired formation of intestinal TRM cells, altered their transcriptional heterogeneity, and increased their differentiation into tissue-confined and recirculating CX3CR1+ effector cells during recall. TGF-β and retinoic acid were required for formation and survival of TCF1- and ID3-expressing TRM cells and restrained their differentiation into CX3CR1+ effector cells during reinfection. Thus, stem-like cells control the quality and recall capacity of TRM cells, thereby contributing to anamnestic memory responses.
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650 _ 7 |a Hepatocyte Nuclear Factor 1-alpha
|2 NLM Chemicals
650 _ 7 |a Hnf1a protein, mouse
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650 _ 7 |a Idb3 protein, mouse
|0 135845-89-5
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650 _ 7 |a Inhibitor of Differentiation Proteins
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650 _ 7 |a CX3C Chemokine Receptor 1
|2 NLM Chemicals
650 _ 7 |a T Cell Transcription Factor 1
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Immunologic Memory: immunology
|2 MeSH
650 _ 2 |a Memory T Cells: immunology
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
|2 MeSH
650 _ 2 |a Intestines: immunology
|2 MeSH
650 _ 2 |a Hepatocyte Nuclear Factor 1-alpha: genetics
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650 _ 2 |a Hepatocyte Nuclear Factor 1-alpha: immunology
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650 _ 2 |a Cell Differentiation: immunology
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650 _ 2 |a Inhibitor of Differentiation Proteins: immunology
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650 _ 2 |a Inhibitor of Differentiation Proteins: genetics
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650 _ 2 |a CX3C Chemokine Receptor 1
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650 _ 2 |a Stem Cells: immunology
|2 MeSH
650 _ 2 |a Mice, Knockout
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650 _ 2 |a T Cell Transcription Factor 1: genetics
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650 _ 2 |a T Cell Transcription Factor 1: immunology
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700 1 _ |a Duarte da Silva, Vinicius A
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700 1 _ |a Potemkin, Nikita
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700 1 _ |a Gabriel, Sarah S
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700 1 _ |a Mason, Teisha
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700 1 _ |a Elmzzahi, Tarek
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700 1 _ |a De Lima Moreira, Marcela
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700 1 _ |a Su, Chun-Hsi
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700 1 _ |a Mackay, Laura
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700 1 _ |a Beyer, Marc D
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700 1 _ |a Schröder, Jan
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700 1 _ |a Gasteiger, Georg
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700 1 _ |a Kallies, Axel
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773 _ _ |a 10.1126/sciimmunol.adw1992
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