%0 Journal Article
%A Onkes, Meike
%A Dahlmann, Paul
%A Gesenhues, Alena
%A Gacula, Sean Ira G
%A Mansour, Nabeel
%A Schweizer, Júnia R O L
%A Stüfchen, Isabel
%A Lottspeich, Christian
%A Wang, Katharina
%A Auer, Matthias K
%A Brendel, Matthias
%A Fischer, Alessa
%A Braunschweig, Till
%A Gildehaus, Franz-Josef
%A Lindner, Simon
%A Schmid-Tannwald, Christine
%A Pfluger, Thomas
%A Auernhammer, Christoph J
%A Nölting, Svenja
%A Werner, Rudolf A
%A Reincke, Martin
%A Bidlingmaier, Martin
%A Kroiss, Matthias
%A Völter, Friederike
%T [18F]SiTATE-PET/CT for detection of pheochromocytomas and paragangliomas: comparison of biochemical secretion, genotype and imaging metrics.
%J European journal of nuclear medicine and molecular imaging
%V 52
%N 13
%@ 1619-7070
%C Heidelberg [u.a.]
%I Springer-Verl.
%M DZNE-2025-01245
%P 5175 - 5188
%D 2025
%X Somatostatin-receptor (SSTR)-targeting PET/CT is widely used for diagnosis and disease monitoring of pheochromocytoma / paraganglioma (PPGL). The aim of this study was to assess the potential of the novel SSTR-targeting tracer [18F]SiTATE in diagnosing PPGL by comparing imaging parameters to tumor marker levels and secretory activity in a small cohort of patients diagnosed with this rare tumor type.This retrospective study included 34 patients with histologically confirmed PPGL who underwent [18F]SiTATE-PET/CT at LMU University Hospital Munich between 10/2020 and 02/2024 as well as hormonal laboratory analysis within up to 100 days. Imaging parameters - standardized uptake values (SUVmax, SUVmean), metabolic tumor volume (MTV), and total lesion uptake (TLU) - were analyzed. Uptake was normalized to liver background (SUVmaxr, SUVmeanr). Radioligand uptake of biochemical subtypes and genotypes was compared with Mann-Whitney-U test. Correlation was tested using Spearman´s rank correlation test.The patient-based detection rate of [18F]SiTATE-PET was 96.6
%K Humans
%K Positron Emission Tomography Computed Tomography
%K Male
%K Pheochromocytoma: diagnostic imaging
%K Pheochromocytoma: genetics
%K Pheochromocytoma: metabolism
%K Female
%K Middle Aged
%K Adrenal Gland Neoplasms: diagnostic imaging
%K Adrenal Gland Neoplasms: genetics
%K Adrenal Gland Neoplasms: metabolism
%K Adult
%K Paraganglioma: diagnostic imaging
%K Paraganglioma: genetics
%K Paraganglioma: metabolism
%K Retrospective Studies
%K Aged
%K Genotype
%K Young Adult
%K Catecholamines (Other)
%K ELISA (Other)
%K LCMS (Other)
%K Molecular imaging (Other)
%K PET/CT (Other)
%K PPGL (Other)
%K Paraganglioma (Other)
%K Pheochromocytoma (Other)
%K SSTR (Other)
%K [18F]SiTATE (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40445313
%2 pmc:PMC12589282
%R 10.1007/s00259-025-07341-9
%U https://pub.dzne.de/record/281874