Journal Article

DZNE-2025-01245

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png [18F]SiTATE-PET/CT for detection of pheochromocytomas and paragangliomas: comparison of biochemical secretion, genotype and imaging metrics.

Onkes, M. ; Dahlmann, P. ; Gesenhues, A. ; Gacula, S. I. G. ; Mansour, N. ; Schweizer, J. R. O. L. ; Stüfchen, I. ; Lottspeich, C. ; Wang, K. ; Auer, M. K. ; Brendel, M.DZNE* ; Fischer, A. ; Braunschweig, T. ; Gildehaus, F.-J. ; Lindner, S. ; Schmid-Tannwald, C. ; Pfluger, T. ; Auernhammer, C. J. ; Nölting, S. ; Werner, R. A. ; Reincke, M. ; Bidlingmaier, M. ; Kroiss, M. ; Völter, F.

2025
Springer-Verl. Heidelberg [u.a.]

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Please use a persistent id in citations: doi:10.1007/s00259-025-07341-9

Abstract: Somatostatin-receptor (SSTR)-targeting PET/CT is widely used for diagnosis and disease monitoring of pheochromocytoma / paraganglioma (PPGL). The aim of this study was to assess the potential of the novel SSTR-targeting tracer [18F]SiTATE in diagnosing PPGL by comparing imaging parameters to tumor marker levels and secretory activity in a small cohort of patients diagnosed with this rare tumor type.This retrospective study included 34 patients with histologically confirmed PPGL who underwent [18F]SiTATE-PET/CT at LMU University Hospital Munich between 10/2020 and 02/2024 as well as hormonal laboratory analysis within up to 100 days. Imaging parameters - standardized uptake values (SUVmax, SUVmean), metabolic tumor volume (MTV), and total lesion uptake (TLU) - were analyzed. Uptake was normalized to liver background (SUVmaxr, SUVmeanr). Radioligand uptake of biochemical subtypes and genotypes was compared with Mann-Whitney-U test. Correlation was tested using Spearman´s rank correlation test.The patient-based detection rate of [18F]SiTATE-PET was 96.6%. A moderate correlation was found between MTV and TLU with chromogranin A (r = 0.570-0.608, p < 0.005) and with biochemical secretion (r = 0.466-0.576, p < 0.05). Hereditary PPGL with Cluster 1 genotype showed stronger [18F]SiTATE uptake compared to sporadic PPGL (SUVmeanr: p = 0.032; SUVmaxr: p = 0.051). A subgroup comparison with [⁶⁸Ga]Ga-DOTATOC-PET/CT revealed no significant difference in uptake metrics or tumor-to-background ratios.This is the first clinical evaluation of [18F]SiTATE-PET/CT in patients with PPGL. MTV and TLU measured with [18F]SiTATE-PET/CT correlated well with the tumor marker chromogranin A in serum and with (nor)metanephrines in urine and plasma. Within the limits imposed by the small cohort, our results suggest that TLU and MTV in [18F]SiTATE-PET/CT could be used as SSTR imaging biomarker for monitoring of disease progression and secretory activity in patients with PPGL.

Keyword(s): Humans (MeSH) ; Positron Emission Tomography Computed Tomography (MeSH) ; Male (MeSH) ; Pheochromocytoma: diagnostic imaging (MeSH) ; Pheochromocytoma: genetics (MeSH) ; Pheochromocytoma: metabolism (MeSH) ; Female (MeSH) ; Middle Aged (MeSH) ; Adrenal Gland Neoplasms: diagnostic imaging (MeSH) ; Adrenal Gland Neoplasms: genetics (MeSH) ; Adrenal Gland Neoplasms: metabolism (MeSH) ; Adult (MeSH) ; Paraganglioma: diagnostic imaging (MeSH) ; Paraganglioma: genetics (MeSH) ; Paraganglioma: metabolism (MeSH) ; Retrospective Studies (MeSH) ; Aged (MeSH) ; Genotype (MeSH) ; Young Adult (MeSH) ; Catecholamines ; ELISA ; LCMS ; Molecular imaging ; PET/CT ; PPGL ; Paraganglioma ; Pheochromocytoma ; SSTR ; [18F]SiTATE

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Contributing Institute(s):

1. Molecular Neurodegeneration (AG Haass)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2025

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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