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@ARTICLE{Onkes:281874,
      author       = {Onkes, Meike and Dahlmann, Paul and Gesenhues, Alena and
                      Gacula, Sean Ira G and Mansour, Nabeel and Schweizer, Júnia
                      R O L and Stüfchen, Isabel and Lottspeich, Christian and
                      Wang, Katharina and Auer, Matthias K and Brendel, Matthias
                      and Fischer, Alessa and Braunschweig, Till and Gildehaus,
                      Franz-Josef and Lindner, Simon and Schmid-Tannwald,
                      Christine and Pfluger, Thomas and Auernhammer, Christoph J
                      and Nölting, Svenja and Werner, Rudolf A and Reincke,
                      Martin and Bidlingmaier, Martin and Kroiss, Matthias and
                      Völter, Friederike},
      title        = {[18{F}]{S}i{TATE}-{PET}/{CT} for detection of
                      pheochromocytomas and paragangliomas: comparison of
                      biochemical secretion, genotype and imaging metrics.},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {52},
      number       = {13},
      issn         = {1619-7070},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {DZNE-2025-01245},
      pages        = {5175 - 5188},
      year         = {2025},
      abstract     = {Somatostatin-receptor (SSTR)-targeting PET/CT is widely
                      used for diagnosis and disease monitoring of
                      pheochromocytoma / paraganglioma (PPGL). The aim of this
                      study was to assess the potential of the novel
                      SSTR-targeting tracer [18F]SiTATE in diagnosing PPGL by
                      comparing imaging parameters to tumor marker levels and
                      secretory activity in a small cohort of patients diagnosed
                      with this rare tumor type.This retrospective study included
                      34 patients with histologically confirmed PPGL who underwent
                      [18F]SiTATE-PET/CT at LMU University Hospital Munich between
                      10/2020 and 02/2024 as well as hormonal laboratory analysis
                      within up to 100 days. Imaging parameters - standardized
                      uptake values (SUVmax, SUVmean), metabolic tumor volume
                      (MTV), and total lesion uptake (TLU) - were analyzed. Uptake
                      was normalized to liver background (SUVmaxr, SUVmeanr).
                      Radioligand uptake of biochemical subtypes and genotypes was
                      compared with Mann-Whitney-U test. Correlation was tested
                      using Spearman´s rank correlation test.The patient-based
                      detection rate of [18F]SiTATE-PET was $96.6\%.$ A moderate
                      correlation was found between MTV and TLU with chromogranin
                      A (r = 0.570-0.608, p < 0.005) and with biochemical
                      secretion (r = 0.466-0.576, p < 0.05). Hereditary PPGL with
                      Cluster 1 genotype showed stronger [18F]SiTATE uptake
                      compared to sporadic PPGL (SUVmeanr: p = 0.032; SUVmaxr: p =
                      0.051). A subgroup comparison with
                      [⁶⁸Ga]Ga-DOTATOC-PET/CT revealed no significant
                      difference in uptake metrics or tumor-to-background
                      ratios.This is the first clinical evaluation of
                      [18F]SiTATE-PET/CT in patients with PPGL. MTV and TLU
                      measured with [18F]SiTATE-PET/CT correlated well with the
                      tumor marker chromogranin A in serum and with
                      (nor)metanephrines in urine and plasma. Within the limits
                      imposed by the small cohort, our results suggest that TLU
                      and MTV in [18F]SiTATE-PET/CT could be used as SSTR imaging
                      biomarker for monitoring of disease progression and
                      secretory activity in patients with PPGL.},
      keywords     = {Humans / Positron Emission Tomography Computed Tomography /
                      Male / Pheochromocytoma: diagnostic imaging /
                      Pheochromocytoma: genetics / Pheochromocytoma: metabolism /
                      Female / Middle Aged / Adrenal Gland Neoplasms: diagnostic
                      imaging / Adrenal Gland Neoplasms: genetics / Adrenal Gland
                      Neoplasms: metabolism / Adult / Paraganglioma: diagnostic
                      imaging / Paraganglioma: genetics / Paraganglioma:
                      metabolism / Retrospective Studies / Aged / Genotype / Young
                      Adult / Catecholamines (Other) / ELISA (Other) / LCMS
                      (Other) / Molecular imaging (Other) / PET/CT (Other) / PPGL
                      (Other) / Paraganglioma (Other) / Pheochromocytoma (Other) /
                      SSTR (Other) / [18F]SiTATE (Other)},
      cin          = {AG Haass},
      ddc          = {610},
      cid          = {I:(DE-2719)1110007},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40445313},
      pmc          = {pmc:PMC12589282},
      doi          = {10.1007/s00259-025-07341-9},
      url          = {https://pub.dzne.de/record/281874},
}