%0 Journal Article
%A Tzilivaki, Alexandra
%A Larkum, Matthew Evan
%A Schmitz, Dietmar
%T Bimodal nonlinear dendrites in PV+ basket cells drive distinct memory-related oscillations.
%J iScience
%V 28
%N 11
%@ 2589-0042
%C St. Louis
%I Elsevier
%M DZNE-2025-01256
%P 113699
%D 2025
%X PV+ FSBCs are critical for modulating hippocampal oscillations, which are essential for memory and behavior. Our research uses biophysical modeling to propose a cellular, dendritic dependent mechanism: these interneurons can dynamically switch their firing patterns by engaging different dendritic integration modes. We predict that PV+ FSBCs can use their supralinear and sublinear dendrites to selectively influence brain rhythms without changes in synaptic input amount. Supralinear dendrites promote high-frequency oscillations and decrease the circuit's excitation/inhibition (E/I) balance. Conversely, sublinear dendrites enhance slow oscillatory power and increase the E/I balance. This bimodal dendritic strategy gives PV+ FSBCs an energy-efficient way to regulate oscillations. It suggests that the specific computations happening within the dendrites of these interneurons can critically shape memory-related brain rhythms. This offers an experimentally testable hypothesis about the subcellular mechanisms of rhythm generation in the hippocampus.
%K Behavioral neuroscience (Other)
%K Biological sciences (Other)
%K Cellular neuroscience (Other)
%K Cognitive neuroscience (Other)
%K Natural sciences (Other)
%K Neuroscience (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41210997
%2 pmc:PMC12590550
%R 10.1016/j.isci.2025.113699
%U https://pub.dzne.de/record/281914