Journal Article

DZNE-2025-01256

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Bimodal nonlinear dendrites in PV+ basket cells drive distinct memory-related oscillations.

Tzilivaki, A. ; Larkum, M. E. ; Schmitz, D. (Last author)DZNE*

2025
Elsevier St. Louis

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Please use a persistent id in citations: doi:10.1016/j.isci.2025.113699

Abstract: PV+ FSBCs are critical for modulating hippocampal oscillations, which are essential for memory and behavior. Our research uses biophysical modeling to propose a cellular, dendritic dependent mechanism: these interneurons can dynamically switch their firing patterns by engaging different dendritic integration modes. We predict that PV+ FSBCs can use their supralinear and sublinear dendrites to selectively influence brain rhythms without changes in synaptic input amount. Supralinear dendrites promote high-frequency oscillations and decrease the circuit's excitation/inhibition (E/I) balance. Conversely, sublinear dendrites enhance slow oscillatory power and increase the E/I balance. This bimodal dendritic strategy gives PV+ FSBCs an energy-efficient way to regulate oscillations. It suggests that the specific computations happening within the dendrites of these interneurons can critically shape memory-related brain rhythms. This offers an experimentally testable hypothesis about the subcellular mechanisms of rhythm generation in the hippocampus.

Keyword(s): Behavioral neuroscience ; Biological sciences ; Cellular neuroscience ; Cognitive neuroscience ; Natural sciences ; Neuroscience

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Contributing Institute(s):

1. Network Dysfunction (AG Schmitz)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

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; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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