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000281914 1001_ $$aTzilivaki, Alexandra$$b0
000281914 245__ $$aBimodal nonlinear dendrites in PV+ basket cells drive distinct memory-related oscillations.
000281914 260__ $$aSt. Louis$$bElsevier$$c2025
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000281914 520__ $$aPV+ FSBCs are critical for modulating hippocampal oscillations, which are essential for memory and behavior. Our research uses biophysical modeling to propose a cellular, dendritic dependent mechanism: these interneurons can dynamically switch their firing patterns by engaging different dendritic integration modes. We predict that PV+ FSBCs can use their supralinear and sublinear dendrites to selectively influence brain rhythms without changes in synaptic input amount. Supralinear dendrites promote high-frequency oscillations and decrease the circuit's excitation/inhibition (E/I) balance. Conversely, sublinear dendrites enhance slow oscillatory power and increase the E/I balance. This bimodal dendritic strategy gives PV+ FSBCs an energy-efficient way to regulate oscillations. It suggests that the specific computations happening within the dendrites of these interneurons can critically shape memory-related brain rhythms. This offers an experimentally testable hypothesis about the subcellular mechanisms of rhythm generation in the hippocampus.
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000281914 650_7 $$2Other$$aBehavioral neuroscience
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000281914 650_7 $$2Other$$aCognitive neuroscience
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000281914 650_7 $$2Other$$aNeuroscience
000281914 7001_ $$aLarkum, Matthew Evan$$b1
000281914 7001_ $$0P:(DE-2719)2810725$$aSchmitz, Dietmar$$b2$$eLast author$$udzne
000281914 773__ $$0PERI:(DE-600)2927064-9$$a10.1016/j.isci.2025.113699$$gVol. 28, no. 11, p. 113699 -$$n11$$p113699$$tiScience$$v28$$x2589-0042$$y2025
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