TY  - JOUR
AU  - Tzilivaki, Alexandra
AU  - Larkum, Matthew Evan
AU  - Schmitz, Dietmar
TI  - Bimodal nonlinear dendrites in PV+ basket cells drive distinct memory-related oscillations.
JO  - iScience
VL  - 28
IS  - 11
SN  - 2589-0042
CY  - St. Louis
PB  - Elsevier
M1  - DZNE-2025-01256
SP  - 113699
PY  - 2025
AB  - PV+ FSBCs are critical for modulating hippocampal oscillations, which are essential for memory and behavior. Our research uses biophysical modeling to propose a cellular, dendritic dependent mechanism: these interneurons can dynamically switch their firing patterns by engaging different dendritic integration modes. We predict that PV+ FSBCs can use their supralinear and sublinear dendrites to selectively influence brain rhythms without changes in synaptic input amount. Supralinear dendrites promote high-frequency oscillations and decrease the circuit's excitation/inhibition (E/I) balance. Conversely, sublinear dendrites enhance slow oscillatory power and increase the E/I balance. This bimodal dendritic strategy gives PV+ FSBCs an energy-efficient way to regulate oscillations. It suggests that the specific computations happening within the dendrites of these interneurons can critically shape memory-related brain rhythms. This offers an experimentally testable hypothesis about the subcellular mechanisms of rhythm generation in the hippocampus.
KW  - Behavioral neuroscience (Other)
KW  - Biological sciences (Other)
KW  - Cellular neuroscience (Other)
KW  - Cognitive neuroscience (Other)
KW  - Natural sciences (Other)
KW  - Neuroscience (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41210997
C2  - pmc:PMC12590550
DO  - DOI:10.1016/j.isci.2025.113699
UR  - https://pub.dzne.de/record/281914
ER  -