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@ARTICLE{Tzilivaki:281914,
      author       = {Tzilivaki, Alexandra and Larkum, Matthew Evan and Schmitz,
                      Dietmar},
      title        = {{B}imodal nonlinear dendrites in {PV}+ basket cells drive
                      distinct memory-related oscillations.},
      journal      = {iScience},
      volume       = {28},
      number       = {11},
      issn         = {2589-0042},
      address      = {St. Louis},
      publisher    = {Elsevier},
      reportid     = {DZNE-2025-01256},
      pages        = {113699},
      year         = {2025},
      abstract     = {PV+ FSBCs are critical for modulating hippocampal
                      oscillations, which are essential for memory and behavior.
                      Our research uses biophysical modeling to propose a
                      cellular, dendritic dependent mechanism: these interneurons
                      can dynamically switch their firing patterns by engaging
                      different dendritic integration modes. We predict that PV+
                      FSBCs can use their supralinear and sublinear dendrites to
                      selectively influence brain rhythms without changes in
                      synaptic input amount. Supralinear dendrites promote
                      high-frequency oscillations and decrease the circuit's
                      excitation/inhibition (E/I) balance. Conversely, sublinear
                      dendrites enhance slow oscillatory power and increase the
                      E/I balance. This bimodal dendritic strategy gives PV+ FSBCs
                      an energy-efficient way to regulate oscillations. It
                      suggests that the specific computations happening within the
                      dendrites of these interneurons can critically shape
                      memory-related brain rhythms. This offers an experimentally
                      testable hypothesis about the subcellular mechanisms of
                      rhythm generation in the hippocampus.},
      keywords     = {Behavioral neuroscience (Other) / Biological sciences
                      (Other) / Cellular neuroscience (Other) / Cognitive
                      neuroscience (Other) / Natural sciences (Other) /
                      Neuroscience (Other)},
      cin          = {AG Schmitz},
      ddc          = {050},
      cid          = {I:(DE-2719)1810004},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41210997},
      pmc          = {pmc:PMC12590550},
      doi          = {10.1016/j.isci.2025.113699},
      url          = {https://pub.dzne.de/record/281914},
}