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100 1 _ |a Tzilivaki, Alexandra
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245 _ _ |a Bimodal nonlinear dendrites in PV+ basket cells drive distinct memory-related oscillations.
260 _ _ |a St. Louis
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520 _ _ |a PV+ FSBCs are critical for modulating hippocampal oscillations, which are essential for memory and behavior. Our research uses biophysical modeling to propose a cellular, dendritic dependent mechanism: these interneurons can dynamically switch their firing patterns by engaging different dendritic integration modes. We predict that PV+ FSBCs can use their supralinear and sublinear dendrites to selectively influence brain rhythms without changes in synaptic input amount. Supralinear dendrites promote high-frequency oscillations and decrease the circuit's excitation/inhibition (E/I) balance. Conversely, sublinear dendrites enhance slow oscillatory power and increase the E/I balance. This bimodal dendritic strategy gives PV+ FSBCs an energy-efficient way to regulate oscillations. It suggests that the specific computations happening within the dendrites of these interneurons can critically shape memory-related brain rhythms. This offers an experimentally testable hypothesis about the subcellular mechanisms of rhythm generation in the hippocampus.
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650 _ 7 |a Behavioral neuroscience
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700 1 _ |a Larkum, Matthew Evan
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700 1 _ |a Schmitz, Dietmar
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773 _ _ |a 10.1016/j.isci.2025.113699
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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