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@ARTICLE{Vieregge:282536,
      author       = {Vieregge, Magdalena and Kuzkina, Anastasia and Janzen,
                      Annette and Oertel, Wolfgang H. and Sommerauer, Michael and
                      Volkmann, Jens and Doppler, Kathrin},
      title        = {{D}ermal {A}lpha‐{S}ynuclein {A}ggregation in {S}eed
                      {A}mplification {A}ssays for {P}arkinson's {D}isease
                      {S}ubtype {D}ifferentiation},
      journal      = {European journal of neurology},
      volume       = {32},
      number       = {12},
      issn         = {1351-5101},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2025-01299},
      pages        = {e70453},
      year         = {2025},
      abstract     = {BackgroundSkin biopsies and seed amplification assays (SAA)
                      provide a sensitive and potentially quantitative method to
                      detect alpha-synuclein (a-syn) aggregation in peripheral
                      nerve fibers in Parkinson's disease (PD). Relating to the
                      previously published hypothesis that PD may either originate
                      in the peripheral (body-first) or central (brain-first)
                      nervous system, we investigated whether patients with
                      clinical features that have been reported to be associated
                      with a suspected body-first subtype of PD exhibit higher
                      levels of a-syn aggregation in dermal nerve fibers compared
                      to those without these features. Patients with isolated REM
                      sleep behavior disorder (iRBD) representing a suspected
                      premotor stage of body-first PD were studied in comparison
                      to the PD cohort.MethodsPatients were categorized on the
                      basis of clinical features, and SAA parameters such as lag
                      time, number of positive curves, and titers were analyzed
                      and correlated with clinical features.ResultsAlthough
                      patients with clinical features of suspected body-first PD
                      showed slightly higher titers, significant differences were
                      mainly observed between iRBD patients and PD
                      patients.ConclusionsOur data suggest that widespread α-syn
                      aggregation in advanced PD limits the use of SAA in skin
                      biopsies for subtype differentiation.},
      cin          = {AG Petzold},
      ddc          = {610},
      cid          = {I:(DE-2719)1013020},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1111/ene.70453},
      url          = {https://pub.dzne.de/record/282536},
}