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@ARTICLE{Vieregge:282536,
      author       = {Vieregge, Magdalena and Kuzkina, Anastasia and Janzen,
                      Annette and Oertel, Wolfgang H. and Sommerauer, Michael and
                      Volkmann, Jens and Doppler, Kathrin},
      title        = {{D}ermal {A}lpha‐{S}ynuclein {A}ggregation in {S}eed
                      {A}mplification {A}ssays for {P}arkinson's {D}isease
                      {S}ubtype {D}ifferentiation},
      journal      = {European journal of neurology},
      volume       = {32},
      number       = {12},
      issn         = {1351-5101},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2025-01299},
      pages        = {e70453},
      year         = {2025},
      abstract     = {Skin biopsies and seed amplification assays (SAA) provide a
                      sensitive and potentially quantitative method to detect
                      alpha-synuclein (a-syn) aggregation in peripheral nerve
                      fibers in Parkinson's disease (PD). Relating to the
                      previously published hypothesis that PD may either originate
                      in the peripheral (body-first) or central (brain-first)
                      nervous system, we investigated whether patients with
                      clinical features that have been reported to be associated
                      with a suspected body-first subtype of PD exhibit higher
                      levels of a-syn aggregation in dermal nerve fibers compared
                      to those without these features. Patients with isolated REM
                      sleep behavior disorder (iRBD) representing a suspected
                      premotor stage of body-first PD were studied in comparison
                      to the PD cohort.Patients were categorized on the basis of
                      clinical features, and SAA parameters such as lag time,
                      number of positive curves, and titers were analyzed and
                      correlated with clinical features.Although patients with
                      clinical features of suspected body-first PD showed slightly
                      higher titers, significant differences were mainly observed
                      between iRBD patients and PD patients.Our data suggest that
                      widespread α-syn aggregation in advanced PD limits the use
                      of SAA in skin biopsies for subtype differentiation.},
      keywords     = {Humans / Parkinson Disease: metabolism / Parkinson Disease:
                      diagnosis / Parkinson Disease: classification / Parkinson
                      Disease: pathology / Parkinson Disease: complications /
                      alpha-Synuclein: metabolism / Male / Female / Aged / Skin:
                      metabolism / Skin: pathology / Skin: innervation / Middle
                      Aged / REM Sleep Behavior Disorder: metabolism / Parkinson's
                      disease (Other) / REM sleep behavior disorder (Other) /
                      alpha‐synuclein (Other) / seeding amplification assay
                      (Other) / skin biopsy (Other) / alpha-Synuclein (NLM
                      Chemicals)},
      cin          = {AG Petzold},
      ddc          = {610},
      cid          = {I:(DE-2719)1013020},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41316710},
      pmc          = {pmc:PMC12662814},
      doi          = {10.1111/ene.70453},
      url          = {https://pub.dzne.de/record/282536},
}